Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 7/20 | 0.49 |
| ▸ | UBE2B | P63146 | 1/20 | 0.49 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | CDK1 | P06493 | 4/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | ULK1 | O75385 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1163979 | 0.86 | PTK2 (0.54) | PTK2 | |
| SCHEMBL24752394 | 0.79 | PTK2 (0.52) | PTK2GLO1GSK3AGSK3BCDK1 | |
| SCHEMBL2523864 | 0.79 | GLO1 (0.54) | PTK2GLO1GSK3AGSK3BKDR | |
| SCHEMBL30002940 | 0.75 | GSK3A (0.51) | PTK2GLO1GSK3AGSK3BKDR | |
| SCHEMBL1163656 | 0.74 | PTK2 (0.55) | PTK2 | |
| SCHEMBL1163738 | 0.73 | PTK2 (0.67) | PTK2 | |
| SCHEMBL523154 | 0.72 | KMT2A (0.67) | NPC1MAPTRAB9A | |
| SCHEMBL2520165 | 0.70 | PTK2 (0.54) | PTK2GLO1GSK3AGSK3BCDK1 | |
| SCHEMBL16695904 | 0.70 | HTR2A (0.56) | NPC1MAPTRAB9APKM | |
| SCHEMBL28766797 | 0.69 | HTT (0.69) | NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367799-B1 | 2-AMINO-5-TRIFLUOROMETHYL-PYRIMIDINE DERIVATIVES AND THEIR USE AS PTK2 KINASE INHIBITORS | IPHARMA H K LTD (HK) | 2018-08-01 | — | — | EP | claimed |
| EP-2367799-B1 | 2-AMINO-5-TRIFLUOROMETHYL-PYRIMIDINE DERIVATIVES AND THEIR USE AS PTK2 KINASE INHIBITORS | IPHARMA H K LTD (HK) | 2018-08-01 | — | — | EP | disclosed |