SCHEMBL1164153

SCHEMBL1164153

CC1=C(Br)C(=O)NC1=O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL845296 0.79
SCHEMBL10830328 0.76 EGFR (0.33)
SCHEMBL10830337 0.76 EGFR (0.33)
SCHEMBL11375724 0.73 EGFR (0.32)
SCHEMBL996564 0.71 PTGS2 (0.33)
SCHEMBL3470127 0.67
SCHEMBL3469703 0.67
SCHEMBL17225992 0.67 KDM4E (0.30)
SCHEMBL13287284 0.67
SCHEMBL18835139 0.65 CA1 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2948177-A1 METHODS FOR OPTIMIZING DOMAIN STABILITY OF BINDING PROTEINS AbbVie Inc. (US) 2015-12-02 EP claimed
WO-2014116596-A1 METHODS FOR OPTIMIZING DOMAIN STABILITY OF BINDING PROTEINS ABBVIE, INC. (US) 2014-07-31 WO claimed
EP-2464972-A1 REVERSIBLE COVALENT LINKAGE OF FUNCTIONAL MOLECULES UCL Business PLC (GB) 2012-06-20 EP disclosed
EP-2464974-A1 FUNCTIONALISATION OF SOLID SUBSTRATES UCL Business PLC (GB) 2012-06-20 EP disclosed
EP-2464654-A2 THIOL PROTECTING GROUP UCL Business PLC (GB) 2012-06-20 EP disclosed
WO-2011018613-A1 FUNCTIONALISATION OF SOLID SUBSTRATES UCL BUSINESS PLC (GB) 2011-02-17 WO disclosed
WO-2011018611-A1 REVERSIBLE COVALENT LINKAGE OF FUNCTIONAL MOLECULES UCL BUSINESS PLC (GB) 2011-02-17 WO disclosed
WO-2011018612-A2 THIOL PROTECTING GROUP UCL BUSINESS PLC (GB) 2011-02-17 WO disclosed
EP-2167083-A2 NOVEL 1- HETEROARYL-3-AZABICYCLOÝ3.1.0¨HEXANES, METHODS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS DOV Pharmaceutical, Inc. (US) 2010-03-31 EP disclosed
WO-2008153937-A2 NOVEL 1- HETEROARYL-3-AZABICYCLO[3.1.0]HEXANES, METHODS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS DOV PHARMACEUTICAL, INC. (US) 2008-12-18 WO disclosed
EP-1915148-A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROPATHIES AND RELATED DISORDERS DOV Pharmaceutical, Inc. (US) 2008-04-30 EP disclosed
WO-2007014264-A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROPATHIES AND RELATED DISORDERS DOV PHARMACEUTICAL, INC. (US) 2007-02-01 WO disclosed