SCHEMBL1164512

SCHEMBL1164512

FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)c1cc(C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)c2ccc3c(C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)cc(C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)c4ccc1c2c43

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.33
KDM4E B2RXH2 1/20 0.32
MEN1 O00255 1/20 0.32
MAPT P10636 1/20 0.32
MAPK1 P28482 1/20 0.32
HTT P42858 1/20 0.32
KMT2A Q03164 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19750289 0.76 LMNA (0.35) LMNAKDM4EMAPTSMN1; SMN2
SCHEMBL19750288 0.76 LMNA (0.35) LMNAKDM4EMAPTSMN1; SMN2
SCHEMBL3868549 0.74 LMNA (0.33) LMNA
SCHEMBL19750290 0.73 ALDH1A1 (0.33) LMNAKDM4EMAPTSMN1; SMN2
SCHEMBL10825970 0.72 LMNA (0.32) LMNAMEN1MAPK1KMT2A
SCHEMBL10794890 0.69 TYR (0.35) LMNAHTT
SCHEMBL8846995 0.69 MAPT (0.35) LMNAMAPT
SCHEMBL674220 0.68 LMNA (0.42) LMNA
SCHEMBL10293003 0.68 LMNA (0.36) LMNA
SCHEMBL11995382 0.68 LMNA (0.36) LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3042890-A2 FLUORINATED AROMATIC MATERIALS AND THEIR USE IN OPTOELECTRONICS The University Of South Dakota (US) 2016-07-13 EP disclosed
US-9246105-B2 Fluorinated aromatic materials and their use in optoelectronics THE UNIVERSITY OF SOUTH DAKOTA (US) 2016-01-26 US disclosed
EP-2467353-B1 FLUORINATED AROMATIC MATERIALS AND THEIR USE IN OPTOELECTRONICS UNIV SOUTH DAKOTA (US) 2016-01-13 EP disclosed
US-20150207078-A1 FLUORINATED AROMATIC MATERIALS AND THEIR USE IN OPTOELECTRONICS THE UNIVERSITY OF SOUTH DAKOTA 2015-07-23 US disclosed
US-9024094-B2 Fluorinated aromatic materials and their use in optoelectronics THE UNIVERSITY OF SOUTH DAKOTA (US) 2015-05-05 US disclosed
US-20120208989-A1 FLUORINATED AROMATIC MATERIALS AND THEIR USE IN OPTOELECTRONICS THE UNIVERSITY OF SOUTH DAKOTA (US) 2012-08-16 US disclosed
EP-2467353-A1 FLUORINATED AROMATIC MATERIALS AND THEIR USE IN OPTOELECTRONICS The University Of South Dakota (US) 2012-06-27 EP disclosed
WO-2011022678-A1 FLUORINATED AROMATIC MATERIALS AND THEIR USE IN OPTOELECTRONICS THE UNIVERSITY OF SOUTH DAKOTA (US) 2011-02-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120208989-A1 FLUORINATED AROMATIC MATERIALS AND THEIR USE IN OPTOELECTRONICS ALK, SLCO2A1, SLCO2B1 LMNA 2442/4885KDM4E 2156/4885MEN1 3669/4885
US-20150207078-A1 FLUORINATED AROMATIC MATERIALS AND THEIR USE IN OPTOELECTRONICS ALK, SLCO2A1, SLCO2B1 LMNA 2442/4885KDM4E 2156/4885MEN1 3669/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.