SCHEMBL11650002

SCHEMBL11650002

CNC(C)C1CCC(=O)c2ccccc21

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
XIAP P98170 1/20 0.36
BIRC3 Q13489 1/20 0.36
TSHR P16473 4/20 0.35
HTT P42858 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
PTPN1 P18031 2/20 0.33
PDPK1 O15530 1/20 0.33
PTPRC P08575 1/20 0.33
PTPRF P10586 1/20 0.33
CDC25B P30305 1/20 0.33
PARP1 P09874 1/20 0.33
BCHE P06276 1/20 0.33
ACHE P22303 1/20 0.33
CYP2A6 P11509 1/20 0.33
MAOA P21397 1/20 0.33
MAOB P27338 1/20 0.33
MEN1 O00255 1/20 0.32
POLB P06746 1/20 0.32
KMT2A Q03164 1/20 0.32
ATM Q13315 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11654730 0.98 XIAP (0.37) XIAPBIRC3TSHRHTTL3MBTL1
SCHEMBL18289353 0.83 PTPN1 (0.37) TSHRHTTL3MBTL1PTPN1PTPRC
SCHEMBL7716941 0.74 CYP2A6 (0.42) TSHRHTTL3MBTL1PTPN1PTPRC
SCHEMBL2399842 0.73 PDPK1 (0.58) PDPK1
SCHEMBL8250749 0.71 ACHE (0.41) TSHRPARP1BCHEACHECYP2A6
SCHEMBL14169143 0.71 ACHE (0.41) TSHRPARP1BCHEACHECYP2A6
SCHEMBL13383479 0.71 ACHE (0.41) TSHRPARP1BCHEACHECYP2A6
SCHEMBL1339938 0.71 ACHE (0.41) TSHRPARP1BCHEACHECYP2A6
SCHEMBL9880849 0.69 S100A4 (0.40) CDC25BACHEMAOBMEN1KMT2A
SCHEMBL11078614 0.68 BCHE (0.38) BCHEACHECYP2A6MAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4082744-A CNS, ANALGESICS, ANTITUSSIVE, SEDATIVES NIHON IYAKUHIN KOGYO CO., LTD. (JA) 1978-04-04 US disclosed
US-4008219-A CNS ANALGESIC, ANTITUSSIVE, SEDATIVE NIHON IYAKUHIN KOGYO CO., LTD. (JA) 1977-02-15 US disclosed