Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.65 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.55 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | NCF1 | P14598 | 1/20 | 0.52 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13293909 | 0.98 | HRH3 (0.69) | HRH3HRH4ALDH1A1KDM4EMBTD1 | |
| SCHEMBL21094080 | 0.98 | HRH3 (0.69) | HRH3HRH4ALDH1A1KDM4EMBTD1 | |
| SCHEMBL14714868 | 0.85 | HRH3 (0.59) | HRH3ALDH1A1SMN1; SMN2 | |
| SCHEMBL16287253 | 0.85 | CHKA (0.69) | HRH3KDM4ENCF1 | |
| SCHEMBL28702946 | 0.85 | HRH3 (0.45) | HRH3HRH4ALDH1A1KDM4EMBTD1 | |
| SCHEMBL16287625 | 0.83 | KDM4E (0.61) | HRH3ALDH1A1KDM4EL3MBTL1POLB | |
| SCHEMBL16307722 | 0.83 | SIGMAR1 (0.59) | HRH3CYP2D6CXCR4SMN1; SMN2 | |
| SCHEMBL578590 | 0.83 | HRH3 (0.65) | HRH3ALDH1A1SMN1; SMN2 | |
| SCHEMBL4119541 | 0.83 | LMNA (0.61) | HRH3ALDH1A1KDM4ENCF1 | |
| SCHEMBL11201497 | 0.82 | HRH3 (0.94) | HRH3HRH4ALDH1A1KDM4EMBTD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9533965-B2 | 2-arylbenzofuran-7-formamide compounds, preparation method and use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2017-01-03 | — | — | US | disclosed |
| US-9533965-B2 | 2-arylbenzofuran-7-formamide compounds, preparation method and use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2017-01-03 | — | — | US | disclosed |
| EP-2813495-B1 | 2-ARYLBENZOFURAN-7-FORMAMIDE COMPOUNDS, PREPARATION METHOD AND USE THEREOF | SHANGHAI INST MATERIA MEDICA (CN) | 2016-09-28 | — | — | EP | disclosed |
| EP-2813495-B1 | 2-ARYLBENZOFURAN-7-FORMAMIDE COMPOUNDS, PREPARATION METHOD AND USE THEREOF | SHANGHAI INST MATERIA MEDICA (CN) | 2016-09-28 | — | — | EP | disclosed |
| EP-2813495-A1 | 2-ARYLBENZOFURAN-7-FORMAMIDE COMPOUNDS, PREPARATION METHOD AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2014-12-17 | — | — | EP | disclosed |
| EP-2813495-A1 | 2-ARYLBENZOFURAN-7-FORMAMIDE COMPOUNDS, PREPARATION METHOD AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2014-12-17 | — | — | EP | disclosed |
| EP-2451790-A1 | HISTONE DEACETYLASE INHIBITORS | Anthem Biosciences Private Limited (IN) | 2012-05-16 | — | — | EP | disclosed |
| US-20120101099-A1 | HISTONE DEACETYLASE INHIBITORS | ANTHEM BIOSCIENCES PRIVATE LIMITED (IN) | 2012-04-26 | — | — | US | disclosed |
| US-20120101099-A1 | HISTONE DEACETYLASE INHIBITORS | ANTHEM BIOSCIENCES PRIVATE LIMITED (IN) | 2012-04-26 | — | — | US | disclosed |
| US-20120101099-A1 | HISTONE DEACETYLASE INHIBITORS | ANTHEM BIOSCIENCES PRIVATE LIMITED (IN) | 2012-04-26 | — | — | US | disclosed |
| WO-2011021209-A1 | HISTONE DEACETYLASE INHIBITORS | PORTSMOUTH TECHNOLOGIES LLC (US) | 2011-02-24 | — | — | WO | disclosed |
| WO-2011021209-A1 | HISTONE DEACETYLASE INHIBITORS | PORTSMOUTH TECHNOLOGIES LLC (US) | 2011-02-24 | — | — | WO | disclosed |
| EP-2229377-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | Wyeth LLC (US) | 2010-09-22 | — | — | EP | disclosed |
| US-7592373-B2 | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-09-22 | — | — | US | disclosed |
| WO-2009076602-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | WYETH (US) | 2009-06-18 | — | — | WO | disclosed |
| EP-1708698-A1 | 3-(4-PIPERIDINE-1YLMETHYL-PHENYL)-PROPION ACID-PHENYLAMIDE-DERIVATIVES AND RELATED COMPOUNDS USED IN THE FORM OF MCH ANTAGONISTS (MELANINE CONCENTRATING HORMONE) FOR TREATING EATING DISORDERS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005063239-A9 | 3-(4-PIPERIDINE-1YLMETHYL-PHENYL)-PROPION ACID-PHENYLAMIDE-DERIVATIVES AND RELATED COMPOUNDS USED IN THE FORM OF MCH ANTAGONISTS (MELANINE CONCENTRATING HORMONE) FOR TREATING EATING DISORDERS | BOEHRINGER INGELHEIM INT (DE) | 2006-03-09 | — | — | WO | disclosed |
| US-20050267093-A1 | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-12-01 | — | — | US | disclosed |
| WO-2005063239-A1 | 3-(4-PIPERIDINE-1YLMETHYL-PHENYL)-PROPION ACID-PHENYLAMIDE-DERIVATIVES AND RELATED COMPOUNDS USED IN THE FORM OF MCH ANTAGONISTS (MELANINE CONCENTRATING HORMONE) FOR TREATING EATING DISORDERS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-07-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101099-A1 | HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC3, HDAC11 | HRH3 544/4885HRH4 1464/4885ALDH1A1 906/4885 |
| US-20050267093-A1 | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds | MCHR1, MC4R, MCHR2 | HRH3 129/4885HRH4 83/4885ALDH1A1 4302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.