Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11744137 | 0.90 | PLA2G1B (0.39) | PLA2G1BATG4BMCL1KMT2AKDM4E | |
| SCHEMBL11652068 | 0.86 | ACLY (0.44) | PLA2G1BATG4BMCL1KMT2AKDM4E | |
| SCHEMBL11653139 | 0.75 | MCL1 (0.47) | PLA2G1BATG4BMCL1KMT2AMEN1 | |
| SCHEMBL13814014 | 0.70 | ABCB11 (0.42) | KMT2AKDM4EMEN1HSD17B10TSHR | |
| SCHEMBL31612525 | 0.70 | ABCB11 (0.42) | KMT2AKDM4EMEN1HSD17B10TSHR | |
| SCHEMBL31612522 | 0.70 | ABCB11 (0.44) | KMT2AKDM4EMEN1HSD17B10TSHR | |
| SCHEMBL8666830 | 0.66 | ABCB11 (0.50) | KMT2AKDM4EMEN1HSD17B10ALDH1A1 | |
| SCHEMBL29407367 | 0.65 | ABCB11 (0.38) | KMT2AKDM4EMEN1HSD17B10TSHR | |
| SCHEMBL11655008 | 0.65 | HSD17B10 (0.42) | MCL1KMT2AMEN1HSD17B10ACLY | |
| SCHEMBL13966789 | 0.63 | ABCB11 (0.39) | KMT2AKDM4EMEN1HSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4123553-A | ANTHELMINTICS | HOFFMANN-LA ROCHE INC. (US) | 1978-10-31 | — | — | US | claimed |
| US-4034110-A | Anthelmintics effective against liver flukes | HOFFMANN-LA ROCHE INC. (US) | 1977-07-05 | — | — | US | claimed |
| US-4123553-A | ANTHELMINTICS | HOFFMANN-LA ROCHE INC. (US) | 1978-10-31 | — | — | US | disclosed |
| US-4034110-A | Anthelmintics effective against liver flukes | HOFFMANN-LA ROCHE INC. (US) | 1977-07-05 | — | — | US | disclosed |