Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | NPY1R | P25929 | 1/20 | 0.64 |
| ▸ | NPY2R | P49146 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | SCN1A | P35498 | 5/20 | 0.55 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.55 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11653579 | 0.94 | LMNA (0.62) | LMNANPY1RNPY2RKMT2AMEN1 | |
| SCHEMBL11660135 | 0.90 | SCN5A (0.68) | LMNANPY1RNPY2RKMT2AMEN1 | |
| SCHEMBL11659602 | 0.88 | SCN1A (0.56) | LMNANPY1RNPY2RKMT2AMEN1 | |
| SCHEMBL11656901 | 0.88 | MEN1 (0.63) | LMNANPY1RNPY2RKMT2AMEN1 | |
| SCHEMBL11659363 | 0.86 | SCN1A (0.53) | LMNANPY1RNPY2RKMT2AMEN1 | |
| SCHEMBL11387261 | 0.84 | SCN1A (0.54) | LMNANPY1RNPY2RKMT2AMEN1 | |
| SCHEMBL11657132 | 0.84 | SCN5A (0.66) | LMNANPY1RNPY2RKMT2AMEN1 | |
| SCHEMBL11392605 | 0.84 | SCN1A (0.48) | LMNANPY1RNPY2RKMT2AMEN1 | |
| SCHEMBL11389507 | 0.83 | HTR1A (0.61) | LMNAADRB2ADRB1ADRB3 | |
| Hydrochloric Acid SCHEMBL11390065 | 0.82 | HTR1A (0.60) | LMNAADRB2ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4075335-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1978-02-21 | — | — | US | claimed |
| US-3956335-A | HYPERTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1976-05-11 | — | — | US | claimed |
| US-20210187111-A1 | COMPOSITIONS AND METHODS FOR DISRUPTING A MACROPHAGE NETWORK | SCRIPPS HEALTH (US) | 2021-06-24 | — | — | US | disclosed |
| WO-2020018434-A1 | COMPOSITIONS AND METHODS FOR DISRUPTING A MACROPHAGE NETWORK | SCRIPPS HEALTH (US) | 2020-01-23 | — | — | WO | disclosed |
| US-4075335-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1978-02-21 | — | — | US | disclosed |
| US-4075208-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1978-02-21 | — | — | US | disclosed |
| US-3956335-A | HYPERTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1976-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210187111-A1 | COMPOSITIONS AND METHODS FOR DISRUPTING A MACROPHAGE NETWORK | MSR1, CD68, CD209 | LMNA 1723/4885NPY1R 4836/4885NPY2R 4829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.