Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | APAF1 | O14727 | 2/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 5/20 | 0.38 |
| ▸ | LPAR3 | Q9UBY5 | 5/20 | 0.38 |
| ▸ | LPAR5 | Q9H1C0 | 4/20 | 0.38 |
| ▸ | LPAR2 | Q9HBW0 | 4/20 | 0.38 |
| ▸ | LPAR6 | P43657 | 3/20 | 0.38 |
| ▸ | LPAR4 | Q99677 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11654205 | 0.98 | USP2 (0.43) | LTA4HUSP2HTTTSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL9438410 | 0.95 | LTA4H (0.43) | LTA4HHIF1ATSHRALDH1A1LMNA | |
| Bromide SCHEMBL19809585 | 0.91 | LTA4H (0.43) | LTA4HHIF1ATSHRALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL11657022 | 0.87 | HIF1A (0.43) | LTA4HHIF1ATSHRALDH1A1LMNA | |
| Bromide SCHEMBL11659210 | 0.83 | HIF1A (0.43) | LTA4HHIF1ATSHRALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL1097165 | 0.79 | HIF1A (0.46) | LTA4HHIF1ATSHRTP53ALDH1A1 | |
| Hydrochloric Acid SCHEMBL30084976 | 0.78 | HIF1A (0.41) | HIF1ATSHRALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL30084961 | 0.78 | HIF1A (0.41) | HIF1ATSHRMAPK1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1781301 | 0.75 | HIF1A (0.39) | HIF1ATSHRALDH1A1 | |
| Iodide SCHEMBL8002981 | 0.75 | HIF1A (0.46) | LTA4HHIF1ATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4066663-A | 6,11-Dihydrodibenzo-[b. e.]-thiepin-11-one-3-aldehyde and 3-acetal derivatives | SYNTEX (U.S.A.) INC. (US) | 1978-01-03 | — | — | US | disclosed |