Pyrrolidine

Pyrrolidine

SCHEMBL11664741

C1CCNC1.NCP(=O)(O)O

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.40
OTC P00480 1/20 0.40
ANPEP P15144 3/20 0.36
ERAP2 Q6P179 3/20 0.36
FDPS P14324 4/20 0.35
LMNA P02545 2/20 0.35
CYP3A4 P08684 1/20 0.35
NFKB1 P19838 1/20 0.35
BLM P54132 1/20 0.35
PMP22 Q01453 1/20 0.35
CXCR4 P61073 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
ADRB3 P13945 1/20 0.32
PDE4D Q08499 1/20 0.32
PDE3A Q14432 1/20 0.32
GABBR2 O75899 1/20 0.32
GABBR1 Q9UBS5 1/20 0.32
KDM4E B2RXH2 1/20 0.32
MMP2 P08253 1/20 0.32
THRB P10828 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Piperidine SCHEMBL11663522 0.97 ALDH1A1 (0.45) ALDH1A1OTCANPEPERAP2FDPS
Pyrrolidine SCHEMBL27735935 0.80 ALDH1A1 (0.47) ALDH1A1ANPEPERAP2FDPSCXCR4
Pyrrolidine SCHEMBL23354581 0.80 ALDH1A1 (0.53) ALDH1A1FDPSCYP3A4BLMPMP22
Pyrrolidine SCHEMBL28575035 0.80 ALDH1A1 (0.53) ALDH1A1FDPSCYP3A4BLMPMP22
Pyrrolidine SCHEMBL29601650 0.80 ALDH1A1 (0.53) ALDH1A1FDPSCYP3A4BLMPMP22
Morpholine SCHEMBL11664356 0.78 MEN1 (0.48) ALDH1A1OTCANPEPERAP2LMNA
Piperidine SCHEMBL5874248 0.77 ALDH1A1 (0.60) ALDH1A1FDPSCXCR4SMN1; SMN2MMP2
Piperidine SCHEMBL5874242 0.77 ALDH1A1 (0.60) ALDH1A1FDPSCXCR4SMN1; SMN2MMP2
Piperidine SCHEMBL9857707 0.77 ALDH1A1 (0.60) ALDH1A1FDPSCXCR4SMN1; SMN2MMP2
Pyrrolidine SCHEMBL28409763 0.77 ALDH1A1 (0.50) ALDH1A1FDPSCXCR4SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4127401-A Aminomethanephosphonic acid compounds containing plant-growth regulant compositions BAYER AKTIENGESELLSCHAFT (DE) 1978-11-28 US disclosed