Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A4 | P26447 | 2/20 | 0.49 |
| ▸ | EDNRB | P24530 | 6/20 | 0.48 |
| ▸ | EDNRA | P25101 | 6/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.41 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.41 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.41 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.41 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.41 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.41 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7145595 | 0.84 | MEN1 (0.50) | S100A4EDNRBEDNRACYP1A2MAPK1 | |
| SCHEMBL10933413 | 0.79 | EDNRB (0.50) | S100A4EDNRBEDNRACYP1A2MAPK1 | |
| SCHEMBL11487158 | 0.78 | S100A4 (0.46) | S100A4EDNRBEDNRACYP1A2MAPK1 | |
| SCHEMBL155593 | 0.72 | S100A4 (0.87) | S100A4MAPK1HTTALDH1A1MAPT | |
| Anthraquinone SCHEMBL10531854 | 0.72 | S100A4 (0.87) | S100A4MAPK1HTTALDH1A1MAPT | |
| SCHEMBL29378883 | 0.72 | S100A4 (0.87) | S100A4MAPK1HTTALDH1A1MAPT | |
| SCHEMBL9765532 | 0.71 | S100A4 (0.50) | S100A4EDNRBEDNRACYP1A2MAPK1 | |
| SCHEMBL8675120 | 0.70 | S100A4 (0.83) | S100A4CYP1A2MAPK1HTTALDH1A1 | |
| SCHEMBL301388 | 0.70 | S100A4 (0.91) | S100A4MAPK1HTTALDH1A1MAPT | |
| SCHEMBL38651099 | 0.70 | S100A4 (0.91) | S100A4MAPK1HTTALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4015003-A | Antidepressant 1,1a,6,10b-tetrahydrodibenzo[a,e]-cyclopropa-[c]-cyclohepten-6-substituted oximes | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-03-29 | — | — | US | disclosed |
| US-4014936-A | Antidepressant 1,1a,6,10b-tetrahydrodibenzo[a,e]-cyclopropa-[c]-cyclohepten-6-substituted oximes | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-03-29 | — | — | US | disclosed |
| US-4008331-A | Antidepressant 1,1a,6,10b-tetrahydrodibenzo-[a,e]-cyclopropa-[c]-cyclohepten-6-substituted oximes | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-02-15 | — | — | US | disclosed |
| US-3960956-A | Antidepressant 1,1a,6,10b-tetrahydrodibenzo(a,e)-cyclo-propa(c) cyclohepten-6-substituted oximes | E. I. DU PONT DE NEMOURS & COMPANY (US) | 1976-06-01 | — | — | US | disclosed |