Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CDC25B | P30305 | 1/20 | 0.50 |
| ▸ | EDNRB | P24530 | 2/20 | 0.48 |
| ▸ | EDNRA | P25101 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | APAF1 | O14727 | 1/20 | 0.42 |
| ▸ | TERT | O14746 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.42 |
| ▸ | TDP2 | O95551 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11669778 | 0.84 | S100A4 (0.49) | EDNRBEDNRAMAPK1CYP1A2KDM4E | |
| SCHEMBL6903914 | 0.77 | MAPK1 (0.67) | MEN1KMT2ACDC25BEDNRBEDNRA | |
| SCHEMBL28864153 | 0.73 | MEN1 (0.52) | MEN1KMT2ACDC25BEDNRBEDNRA | |
| SCHEMBL8087901 | 0.73 | MEN1 (0.52) | MEN1KMT2ACDC25BEDNRBEDNRA | |
| SCHEMBL5436457 | 0.73 | EDNRB (0.55) | MEN1KMT2ACDC25BEDNRBEDNRA | |
| SCHEMBL6901219 | 0.73 | CDC25B (0.52) | MEN1KMT2ACDC25BEDNRBEDNRA | |
| SCHEMBL28480527 | 0.73 | MEN1 (0.52) | MEN1KMT2ACDC25BEDNRBEDNRA | |
| SCHEMBL6904734 | 0.73 | MEN1 (0.52) | MEN1KMT2ACDC25BEDNRBEDNRA | |
| SCHEMBL8087837 | 0.73 | MEN1 (0.52) | MEN1KMT2ACDC25BEDNRBEDNRA | |
| SCHEMBL6902840 | 0.73 | MEN1 (0.52) | MEN1KMT2ACDC25BEDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6521755-B1 | Process for preparing 10,11-methanobenzosuberane derivatives | ELI LILLY AND COMPANY | 2003-02-18 | — | — | US | disclosed |
| EP-1189887-A2 | PROCESS FOR PREPARING 10,11-METHANOBENZOSUBERANE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-03-27 | — | — | EP | disclosed |
| WO-2000075121-A2 | PROCESS FOR PREPARING 10,11-METHANOBENZOSUBERANE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2000-12-14 | — | — | WO | disclosed |
| US-6087365-A | TREATING DRUG-RESISTANT MALARIA IN A MAMMAL | ELI LILLY AND COMPANY | 2000-07-11 | — | — | US | disclosed |
| US-5889007-A | CHEMISENSITIZING AGENTS; CANCER THERAPY DRUG RESISTANCE | SYNTEX (U.S.A.) INC. (US) | 1999-03-30 | — | — | US | disclosed |
| US-5874434-A | SENSITIZERS FOR CANCER DRUGS | SYNTEX (U.S.A.) INC. (US) | 1999-02-23 | — | — | US | disclosed |
| EP-0695293-B1 | 10,11-METHANODIBENZOSUBERANE DERIVATIVES USED AS CHEMOSENSITIZING AGENTS | SYNTEX INC (US) | 1998-10-14 | — | — | EP | disclosed |
| EP-0866063-A1 | 10, 11-Methanodibenzosuberane derivatives used as chemosensitizing agents | SYNTEX (U.S.A.) INC. (US) | 1998-09-23 | — | — | EP | disclosed |
| US-5654304-A | CHEMOSENSITIZING AGENTS; CANCER THERAPY; DRUG RESISTANCE | SYNTEX (U.S.A.) INC. (US) | 1997-08-05 | — | — | US | disclosed |
| US-5643909-A | CHEMICAL SENSITIZERS FOR CANCER CHEMOTHERAPY FOR MULTIDRUG RESISTANCE | SYNTEX (U.S.A.) INC. (US) | 1997-07-01 | — | — | US | disclosed |
| EP-0695293-A1 | 10,11-METHANODIBENZOSUBERANE DERIVATIVES USED AS CHEMOSENSITIZING AGENTS | SYNTEX (U.S.A.) INC. (US) | 1996-02-07 | — | — | EP | disclosed |
| WO-1994024107-A1 | 10,11-METHANODIBENZOSUBERANE DERIVATIVES USED AS CHEMOSENSITIZING AGENTS | SYNTEX (U.S.A.) INC. (US) | 1994-10-27 | — | — | WO | disclosed |
| US-4045432-A | Antidepressant 1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]-cyclohepten-6-substituted oximes | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-08-30 | — | — | US | disclosed |
| US-4015003-A | Antidepressant 1,1a,6,10b-tetrahydrodibenzo[a,e]-cyclopropa-[c]-cyclohepten-6-substituted oximes | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-03-29 | — | — | US | disclosed |
| US-4014936-A | Antidepressant 1,1a,6,10b-tetrahydrodibenzo[a,e]-cyclopropa-[c]-cyclohepten-6-substituted oximes | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-03-29 | — | — | US | disclosed |
| US-4008331-A | Antidepressant 1,1a,6,10b-tetrahydrodibenzo-[a,e]-cyclopropa-[c]-cyclohepten-6-substituted oximes | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-02-15 | — | — | US | disclosed |
| US-3960956-A | Antidepressant 1,1a,6,10b-tetrahydrodibenzo(a,e)-cyclo-propa(c) cyclohepten-6-substituted oximes | E. I. DU PONT DE NEMOURS & COMPANY (US) | 1976-06-01 | — | — | US | disclosed |
| US-3855295-A | 6-{8 SPIRO-4{40 -(OPTIONALLY SUBSTITUED AMINO) CYCLOHEXYL{9 -1,1a,6,10b-TETRAHYDRODIBENZO {8 a,e{9 CYCLOPROPA{8 c{9 CYCLOHEPTENES | SEARLE & CO | 1974-12-17 | — | — | US | disclosed |