Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EYA3 | Q99504 | 5/20 | 0.64 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.64 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | TTR | P02766 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6345467 | 0.90 | EYA3 (0.71) | EYA3SLC22A12PTPN1CYP2C19CYP2C9 | |
| SCHEMBL11845240 | 0.88 | EYA3 (0.64) | EYA3SLC22A12PTPN1CYP2C19CYP2C9 | |
| SCHEMBL11851974 | 0.84 | CYP2C19 (0.70) | EYA3SLC22A12PTPN1CYP2C19CYP2C9 | |
| SCHEMBL11844578 | 0.83 | EYA3 (0.59) | EYA3SLC22A12PTPN1CYP2C19CYP2C9 | |
| SCHEMBL11734971 | 0.81 | EYA3 (0.57) | EYA3SLC22A12PTPN1CYP2C19CYP2C9 | |
| Benzarone SCHEMBL555497 | 0.79 | EYA3 (1.00) | EYA3SLC22A12PTPN1CYP2C19CYP2C9 | |
| Benzarone SCHEMBL29576057 | 0.79 | EYA3 (1.00) | EYA3SLC22A12PTPN1CYP2C19CYP2C9 | |
| SCHEMBL11673106 | 0.78 | APP (0.55) | CYP2C19CYP2C9SMN1; SMN2LMNAHTT | |
| SCHEMBL6342546 | 0.78 | EYA3 (0.70) | EYA3SLC22A12PTPN1CYP2C19CYP2C9 | |
| SCHEMBL11730698 | 0.78 | L3MBTL1 (0.62) | EYA3SLC22A12PTPN1CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4024273-A | Coronary vasodilator and anti-anginal compositions comprising substituted benzofurans and benzothiophenes and methods of producing coronary vasodilation and anti-anginal activity | SMITHKLINE CORPORATION (US) | 1977-05-17 | — | — | US | disclosed |
| US-3983245-A | CORONARY VASODILATORS | SMITHKLINE CORPORATION (US) | 1976-09-28 | — | — | US | disclosed |
| US-3975537-A | SUBSTITUTED BENZOFURANS | SMITH KLINE (US) | 1976-08-17 | — | — | US | disclosed |
| US-3947470-A | CORONARY VASODILATORS, TREATMENT OF ANGINA PECTORIS | SMITHKLINE CORPORATION (US) | 1976-03-30 | — | — | US | disclosed |