Benzarone

Benzarone

SCHEMBL555497

CCc1oc2ccccc2c1C(=O)c1ccc(O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EYA3 Q99504 6/20 1.00
SLC22A12 Q96S37 6/20 1.00
CYP2C9 P11712 7/20 0.82
PTPN1 P18031 2/20 0.76
CYP2C19 P33261 7/20 0.73
MEN1 O00255 2/20 0.69
ABCB11 O95342 2/20 0.69
LMNA P02545 2/20 0.69
TTR P02766 2/20 0.69
PGR P06401 2/20 0.69
ADRA2A P08913 2/20 0.69
TBXA2R P21731 2/20 0.69
OPRM1 P35372 2/20 0.69
SLC6A3 Q01959 2/20 0.69
KMT2A Q03164 2/20 0.69
BIRC5 O15392 1/20 0.69
HTR1A P08908 1/20 0.69
DRD1 P21728 1/20 0.69
PTGS1 P23219 1/20 0.69
SLC6A2 P23975 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzarone SCHEMBL29576057 1.00 EYA3 (1.00) EYA3SLC22A12CYP2C9PTPN1CYP2C19
Benzarone SCHEMBL28587332 0.99 EYA3 (0.97) EYA3SLC22A12CYP2C9PTPN1CYP2C19
SCHEMBL1287913 0.89 EYA3 (0.81) EYA3SLC22A12CYP2C9PTPN1CYP2C19
SCHEMBL11840583 0.89 EYA3 (0.85) EYA3SLC22A12CYP2C9PTPN1CYP2C19
SCHEMBL12286119 0.88 EYA3 (0.79) EYA3SLC22A12CYP2C9PTPN1CYP2C19
SCHEMBL28101771 0.88 EYA3 (0.79) EYA3SLC22A12CYP2C9PTPN1CYP2C19
SCHEMBL27935343 0.88 EYA3 (0.77) EYA3SLC22A12CYP2C9PTPN1CYP2C19
SCHEMBL1287385 0.87 EYA3 (0.77) EYA3SLC22A12CYP2C9PTPN1CYP2C19
SCHEMBL1287970 0.86 EYA3 (1.00) EYA3SLC22A12CYP2C9PTPN1CYP2C19
SCHEMBL1287413 0.85 SLC22A12 (1.00) EYA3SLC22A12CYP2C9PTPN1CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 404 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4525870-A1 METHODS OF TREATING CUSHING'S SYNDROME AND LIVER DISORDERS, AND OF REDUCING LIVER TOXICITY OF OTHER DRUGS ADMINISTERED TO A PATIENT Corcept Therapeutics Incorporated (US) 2025-03-26 EP claimed
US-20250009655-A1 BIPHASIC COMPOSITIONS COMPRISING ONE OR BOTH OF CARBONATE AND PHOSPHATE Natural Extraction Systems, LLC 2025-01-09 US claimed
US-20240315965-A1 COMPOSITIONS AND METHODS RELATED TO PHARMACEUTICAL EXCIPIENTS Natural Extraction Systems, LLC (US) 2024-09-26 US claimed
US-20240245659-A1 Methods of Treating Cushing's Syndrome and Liver Disorders, and of Reducing Liver Toxicity of Other Drugs Administered to a Patient CORCEPT THERAPEUTICS INCORPORATED (US) 2024-07-25 US claimed
WO-2023225282-A1 METHODS OF TREATING CUSHING'S SYNDROME AND LIVER DISORDERS, AND OF REDUCING LIVER TOXICITY OF OTHER DRUGS ADMINISTERED TO A PATIENT CORCEPT THERAPEUTICS INCORPORATED (US) 2023-11-23 WO claimed
US-20230372312-A1 Methods of Treating Cushing's syndrome and Liver Disorders, and of Reducing Liver Toxicity of Other Drugs Administered to a Patient CORCEPT THERAPEUTICS INCORPORATED (US) 2023-11-23 US claimed
WO-2023064318-A1 BIPHASIC COMPOSITIONS COMPRISING ONE OR BOTH OF CARBONATE AND PHOSPHATE Natural Extraction Systems, LLC (US) 2023-04-20 WO claimed
US-20230089351-A1 METHODS RELATED TO BIOACTIVE AGENTS THAT CONVERT FROM ANIONS TO MOLECULES Natural Extraction Systems, LLC (US) 2023-03-23 US claimed
WO-2022182527-A1 COMPOSITIONS AND METHODS RELATED TO PHARMACEUTICAL EXCIPIENTS Natural Extraction Systems, LLC (US) 2022-09-01 WO claimed
WO-2022182523-A1 COMPOSITIONS RELATED TO BIOACTIVE AGENTS THAT CONVERT FROM ANIONS TO MOLECULES Natural Extraction Systems, LLC (US) 2022-09-01 WO claimed
US-20090076174-A1 CONTROL RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS FROM MULTI-ARMED OLIGOMERS BEZWADA BIOMEDICAL, LLC (US) 2009-03-19 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed
WO-1998027899-A1 PROPHYLACTIC SYSTEM WITH VASODILATOR-CONTAINING FILM BENDIS INA K (US) 1998-07-02 WO claimed
EP-0366156-B1 Composition for the treatment of diseases of the veins and the anal region ROSHDY ISMAIL (DE) 1995-01-11 EP claimed
US-4230702-A Readily enterally absorbable pharmaceutical compositions of per se poorly enterally absorbable pharmacologically active agents KALI-CHEMIE PHARMA GMBH (DE) 1980-10-28 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230089351-A1 METHODS RELATED TO BIOACTIVE AGENTS THAT CONVERT FROM ANIONS TO MOLECULES FABP2, FABP4, GUSB EYA3 1388/4885SLC22A12 395/4885CYP2C9 4501/4885
US-20090076174-A1 CONTROL RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS FROM MULTI-ARMED OLIGOMERS MME, CTSA, ALG1 EYA3 4051/4885SLC22A12 4783/4885CYP2C9 2996/4885
US-20240245659-A1 Methods of Treating Cushing's Syndrome and Liver Disorders, and of Reducing Liver Toxicity of Other Drugs Administered to a Patient CYP3A43, NR3C2, CYP3A5 EYA3 1314/4885SLC22A12 2053/4885CYP2C9 47/4885
US-20230372312-A1 Methods of Treating Cushing's syndrome and Liver Disorders, and of Reducing Liver Toxicity of Other Drugs Administered to a Patient CYP3A43, NR3C2, CYP3A5 EYA3 1314/4885SLC22A12 2053/4885CYP2C9 47/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.