Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EYA3 | Q99504 | 6/20 | 0.57 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TTR | P02766 | 2/20 | 0.43 |
| ▸ | PGR | P06401 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11673946 | 0.88 | MTNR1A (0.57) | CYP2C9CYP2C19NR1H4MTNR1AMTNR1B | |
| SCHEMBL6345467 | 0.84 | EYA3 (0.71) | EYA3SLC22A12PTPN1CYP2C9CYP2C19 | |
| SCHEMBL11673511 | 0.80 | APP (0.56) | CYP2C9NR1H4MEN1KMT2AABCB11 | |
| SCHEMBL11615973 | 0.79 | PTPN1 (0.41) | PTPN1MTNR1AMTNR1BLMNAMAPT | |
| SCHEMBL11845240 | 0.77 | EYA3 (0.64) | EYA3SLC22A12PTPN1CYP2C9CYP2C19 | |
| SCHEMBL11672713 | 0.77 | EYA3 (0.64) | EYA3SLC22A12PTPN1CYP2C9CYP2C19 | |
| SCHEMBL11734971 | 0.76 | EYA3 (0.57) | EYA3SLC22A12PTPN1CYP2C9CYP2C19 | |
| SCHEMBL25389098 | 0.76 | CYP2C19 (0.62) | EYA3SLC22A12PTPN1CYP2C9CYP2C19 | |
| SCHEMBL6342546 | 0.75 | EYA3 (0.70) | EYA3SLC22A12PTPN1CYP2C9CYP2C19 | |
| SCHEMBL11851974 | 0.74 | CYP2C19 (0.70) | EYA3SLC22A12PTPN1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4024273-A | Coronary vasodilator and anti-anginal compositions comprising substituted benzofurans and benzothiophenes and methods of producing coronary vasodilation and anti-anginal activity | SMITHKLINE CORPORATION (US) | 1977-05-17 | — | — | US | disclosed |
| US-3947470-A | CORONARY VASODILATORS, TREATMENT OF ANGINA PECTORIS | SMITHKLINE CORPORATION (US) | 1976-03-30 | — | — | US | disclosed |