Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 7/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | CNR1 | P21554 | 3/20 | 0.50 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11672097 | 0.85 | CYP2C19 (0.67) | L3MBTL1CYP2C19ABCG2CNR2KDM4E | |
| SCHEMBL11673784 | 0.82 | APP (0.65) | CNR2ALDH1A1CNR1ATMBCHE | |
| SCHEMBL11673920 | 0.79 | L3MBTL1 (0.92) | L3MBTL1CYP2C19CNR2CNR1ATM | |
| SCHEMBL11673894 | 0.78 | L3MBTL1 (0.69) | L3MBTL1CYP2C19CNR2KDM4EALDH1A1 | |
| SCHEMBL6740929 | 0.78 | CYP2C19 (0.73) | CYP2C19ABCG2ALDH1A1HPGDCYP2C9 | |
| SCHEMBL7068281 | 0.77 | L3MBTL1 (0.67) | L3MBTL1CYP2C19CNR2KDM4EALDH1A1 | |
| SCHEMBL11673385 | 0.76 | APP (0.62) | CNR2ALDH1A1CNR1ATMBCHE | |
| SCHEMBL11729079 | 0.76 | L3MBTL1 (0.77) | L3MBTL1CYP2C19CNR2CNR1ATM | |
| SCHEMBL11673357 | 0.76 | L3MBTL1 (0.62) | L3MBTL1CYP2C19CNR2KDM4EALDH1A1 | |
| SCHEMBL11673907 | 0.76 | L3MBTL1 (0.62) | L3MBTL1CYP2C19ABCG2CNR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4024273-A | Coronary vasodilator and anti-anginal compositions comprising substituted benzofurans and benzothiophenes and methods of producing coronary vasodilation and anti-anginal activity | SMITHKLINE CORPORATION (US) | 1977-05-17 | — | — | US | disclosed |
| US-3947470-A | CORONARY VASODILATORS, TREATMENT OF ANGINA PECTORIS | SMITHKLINE CORPORATION (US) | 1976-03-30 | — | — | US | disclosed |