Fluorene

Fluorene

SCHEMBL11677474

CC(=O)C(C)=O.c1ccc2c(c1)Cc1ccccc1-2

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 2/20 0.58
HTR2C P28335 2/20 0.58
HTR2B P41595 2/20 0.58
ADRA2A P08913 2/20 0.58
SLC6A2 P23975 2/20 0.58
SLC6A4 P31645 2/20 0.58
CYP1A2 P05177 2/20 0.58
SRD5A2 P31213 1/20 0.55
ALDH1A1 P00352 3/20 0.53
RAB9A P51151 6/20 0.53
NPC1 O15118 5/20 0.53
MTNR1A P48039 1/20 0.47
MTNR1B P49286 1/20 0.47
MAPT P10636 2/20 0.47
KDM4E B2RXH2 2/20 0.47
LMNA P02545 1/20 0.47
HPGD P15428 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
BCHE P06276 1/20 0.46
CES1 P23141 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fluorene SCHEMBL2131210 0.91 SRD5A2 (0.60) MAOAHTR2CHTR2BADRA2ASLC6A2
Fluorene SCHEMBL28312612 0.88 SRD5A2 (0.58) MAOAHTR2CHTR2BADRA2ASLC6A2
Fluorene SCHEMBL28751075 0.88 SRD5A2 (0.58) MAOAHTR2CHTR2BADRA2ASLC6A2
Fluorene SCHEMBL27662337 0.88 HTR2B (0.56) MAOAHTR2CHTR2BADRA2ASLC6A2
Fluorene SCHEMBL8840919 0.85 SRD5A2 (0.64) MAOAHTR2CHTR2BADRA2ASLC6A2
Fluorene SCHEMBL27791149 0.85 MAOA (0.67) MAOAHTR2CHTR2BADRA2ASLC6A2
Fluorene SCHEMBL3139239 0.85 MAOA (0.59) MAOAHTR2CHTR2BADRA2ASLC6A2
Fluorene SCHEMBL28112745 0.83 MAOA (0.58) MAOAHTR2CHTR2BADRA2ASLC6A2
Fluorene SCHEMBL275817 0.83 MAOA (0.52) MAOAHTR2CHTR2BADRA2ASLC6A2
Fluorene SCHEMBL2127827 0.83 SRD5A2 (0.53) MAOAHTR2CHTR2BADRA2ASLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4064347-A Bis-basic ketones of fluorene and fluorenone RICHARDSON-MERRELL INC. (US) 1977-12-20 US disclosed