Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Fluorene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | GABRP | O00591 | 1/20 | 0.45 |
| ▸ | GABRD | O14764 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluorene SCHEMBL10010198 | 0.91 | NPC1 (0.50) | MAOANPC1RAB9AALDH1A1KDM4E | |
| Fluorene SCHEMBL23706341 | 0.89 | SRD5A2 (0.44) | MAOANPC1RAB9AALDH1A1KDM4E | |
| Fluorene SCHEMBL28015663 | 0.88 | SRD5A2 (0.43) | MAOANPC1RAB9AALDH1A1KDM4E | |
| Fluorene SCHEMBL7863457 | 0.87 | MAOA (0.54) | MAOANPC1RAB9AALDH1A1KDM4E | |
| Fluorene SCHEMBL8108367 | 0.87 | MAOA (0.54) | MAOANPC1RAB9AALDH1A1KDM4E | |
| Fluorene SCHEMBL3139239 | 0.87 | MAOA (0.59) | MAOANPC1RAB9AALDH1A1KDM4E | |
| Fluorene SCHEMBL27641511 | 0.85 | MAOA (0.58) | MAOANPC1RAB9AALDH1A1KDM4E | |
| Fluorene SCHEMBL27830018 | 0.85 | MAOA (0.58) | MAOANPC1RAB9AALDH1A1KDM4E | |
| Fluorene SCHEMBL28150649 | 0.84 | MAOA (0.62) | MAOANPC1RAB9AALDH1A1KDM4E | |
| Fluorene SCHEMBL31388525 | 0.84 | MAOA (0.68) | MAOANPC1RAB9AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 124 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106242938-B | Fluorene ethylene derivative and synthetic method thereof | 沈阳大学 | 2019-04-23 | — | — | CN | claimed |
| CN-106554453-B | Agricultural light conversion film material and preparation method thereof | 沈阳大学 | 2018-10-09 | — | — | CN | claimed |
| CN-107974080-A | Polyamide moulding composition and the sandwich construction being made from it | EMS专利股份公司 | 2018-05-01 | — | — | CN | claimed |
| CN-106554453-A | Agricultural light conversion film material and preparation method thereof | 沈阳大学 | 2017-04-05 | — | — | CN | claimed |
| CN-106349030-A | Preparation of high stacking density 9,9-bi[3-phenyl-4-(2-hydroxy oxethyl)phenyl]fluorine crystal | 宿迁市永星化工有限公司 | 2017-01-25 | — | — | CN | claimed |
| CN-106242938-A | Fluorene ethylene derivative and synthetic method thereof | 沈阳大学 | 2016-12-21 | — | — | CN | claimed |
| US-8354173-B2 | Powder coating fluoropolymer compositions containing mono-hydroxy aromatic materials | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2013-01-15 | — | — | US | claimed |
| EP-2076566-B1 | POWDER COATING FLUOROPOLYMER COMPOSITIONS CONTAINING MONO-HYDROXY AROMATIC MATERIALS | 3M INNOVATIVE PROPERTIES CO (US) | 2011-08-31 | — | — | EP | claimed |
| US-20100009197-A1 | POWDER COATING FLUOROPOLYMER COMPOSITIONS CONTAINING MONO-HYDROXY AROMATIC MATERIALS | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2010-01-14 | — | — | US | claimed |
| EP-2076566-A2 | POWDER COATING FLUOROPOLYMER COMPOSITIONS CONTAINING MONO-HYDROXY AROMATIC MATERIALS | 3M Innovative Properties Company (US) | 2009-07-08 | — | — | EP | claimed |
| WO-2008048884-A2 | POWDER COATING FLUOROPOLYMER COMPOSITIONS CONTAINING MONO-HYDROXY AROMATIC MATERIALS | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2008-04-24 | — | — | WO | claimed |
| CN-119948078-A | Thermosetting resin composition, cured product thereof, prepreg, fiber-reinforced composite material, and high-pressure gas container | 三菱瓦斯化学株式会社 | 2025-05-06 | — | — | CN | disclosed |
| US-20240166867-A1 | THERMOPLASTIC RESIN AND OPTICAL LENS INCLUDING SAME | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2024-05-23 | — | — | US | disclosed |
| US-11912827-B2 | Poly(imide-ester-amide) copolymer and optical film | DAXIN MATERIALS CORPORATION (TW) | 2024-02-27 | — | — | US | disclosed |
| CN-112745504-B | Poly (imide-ester-amide) copolymer and optical film | 达兴材料股份有限公司 | 2024-01-19 | — | — | CN | disclosed |
| EP-0256454-B1 | PIGMENT COMPOSITION | DAINICHISEIKA COLOR & CHEMICALS MFG. CO. LTD. (JP) | 1993-03-03 | — | — | EP | disclosed |
| US-4767465-A | POLYESTER DISPERSANT | DAINICHISEIKA COLOR & CHEMICALS MFG. CO., LTD. (JP) | 1988-08-30 | — | — | US | disclosed |
| US-4762568-A | PHOSPHORIC ESTER OF A POLYESTER AS DISPERSANT | DAINICHISEIKA COLOR & CHEMICALS MFG. CO., LTD. (JP) | 1988-08-09 | — | — | US | disclosed |
| EP-0256454-A2 | Pigment composition | DAINICHISEIKA COLOR & CHEMICALS MFG. CO. LTD. (JP) | 1988-02-24 | — | — | EP | disclosed |
| EP-0256456-A2 | Pigment composition | DAINICHISEIKA COLOR & CHEMICALS MFG. CO. LTD. (JP) | 1988-02-24 | — | — | EP | disclosed |