Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 8/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | NT5C2 | P49902 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | NT5E | P21589 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TOP2A | P11388 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15709153 | 0.82 | TSHR (0.67) | BRD4SMN1; SMN2TSHRTP53HSD17B10 | |
| SCHEMBL30919395 | 0.82 | TSHR (0.67) | BRD4SMN1; SMN2TSHRTP53HSD17B10 | |
| SCHEMBL22118772 | 0.81 | BRD4 (0.68) | BRD4NPC1RAB9ANT5C2SMN1; SMN2 | |
| SCHEMBL19466078 | 0.80 | NPC1 (0.54) | BRD4NPC1RAB9ANT5C2SMN1; SMN2 | |
| SCHEMBL28669706 | 0.80 | NPC1 (0.63) | BRD4NPC1RAB9ANT5C2SMN1; SMN2 | |
| SCHEMBL3038563 | 0.78 | NPC1 (0.76) | BRD4NPC1RAB9ANT5C2SMN1; SMN2 | |
| SCHEMBL29638098 | 0.77 | NPC1 (0.56) | BRD4NPC1RAB9ANT5C2SMN1; SMN2 | |
| SCHEMBL17372610 | 0.77 | NPC1 (0.56) | BRD4NPC1RAB9ANT5C2SMN1; SMN2 | |
| SCHEMBL28828155 | 0.77 | BRD4 (0.59) | BRD4NPC1RAB9ANT5C2SMN1; SMN2 | |
| SCHEMBL9853721 | 0.76 | SMN1; SMN2 (0.60) | BRD4NT5C2SMN1; SMN2TSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4038480-A | HYPOTENSIVE AGENTS;INCREASE CARDIAC OUTPUT;ENZYME ACTIVATORS | ICN PHARMACEUTICALS, INC. (US) | 1977-07-26 | — | — | US | disclosed |