Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 6/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11681058 | 0.86 | KCNH2 (0.42) | DRD2HTR1AHTR6DRD4SLC6A2 | |
| SCHEMBL11677581 | 0.85 | SIGMAR1 (0.41) | DRD4SIGMAR1 | |
| SCHEMBL11681955 | 0.84 | DRD2 (0.53) | DRD2HTR1AHTR6DRD4SLC6A2 | |
| SCHEMBL11678752 | 0.83 | SLC6A2 (0.53) | DRD2HTR1AHTR6SLC6A2CYP1A2 | |
| SCHEMBL11681427 | 0.82 | DRD4 (0.39) | DRD2HTR1AHTR6DRD4SLC6A2 | |
| SCHEMBL11680405 | 0.82 | DRD2 (0.37) | DRD2HTR1AHTR6DRD4SLC6A2 | |
| SCHEMBL11678344 | 0.82 | SIGMAR1 (0.40) | DRD4SLC6A2CYP1A2CYP2C9OPRM1 | |
| SCHEMBL11677689 | 0.80 | EPHA2 (0.38) | DRD2HTR1AHTR6DRD4SLC6A2 | |
| SCHEMBL11678564 | 0.77 | SLC6A2 (0.35) | DRD2HTR1AHTR6DRD4SLC6A2 | |
| SCHEMBL11679405 | 0.77 | HRH3 (0.53) | DRD2HTR1AHTR6SLC6A2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4017621-A | 2-Morpholinyl tricyclic dibenzazepine compounds | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1977-04-12 | — | — | US | disclosed |