SCHEMBL11682255

SCHEMBL11682255

O=C(NNc1ccc(NC(=S)NCc2ccccc2)cc1)c1ccc(F)cc1

nearest known ligand 0.71

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 2/20 0.64
MAOB P27338 2/20 0.64
MEN1 O00255 6/20 0.58
KMT2A Q03164 6/20 0.58
ALDH1A1 P00352 4/20 0.58
LMNA P02545 2/20 0.58
ALOX12 P18054 1/20 0.58
RECQL P46063 1/20 0.58
GAA P10253 4/20 0.56
MAPT P10636 3/20 0.56
SMN1; SMN2 Q16637 3/20 0.56
MAOA P21397 1/20 0.56
PLA2G1B P04054 1/20 0.55
ATG4B Q9Y4P1 1/20 0.55
POLB P06746 3/20 0.54
TDP1 Q9NUW8 2/20 0.54
MAPK1 P28482 1/20 0.53
NPSR1 Q6W5P4 1/20 0.53
RAB9A P51151 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11683179 0.88 MAPT (0.71) HDAC1MAOBMEN1KMT2AALDH1A1
SCHEMBL11684110 0.86 MEN1 (0.64) MEN1KMT2AALDH1A1LMNAALOX12
SCHEMBL18807464 0.84 MAOB (0.88) MAOBMEN1KMT2AALDH1A1LMNA
SCHEMBL8614130 0.83 MAOB (0.71) HDAC1MAOBMEN1KMT2AALDH1A1
SCHEMBL4893276 0.82 ALDH1A1 (0.66) HDAC1MEN1KMT2AALDH1A1LMNA
SCHEMBL28647479 0.79 MAOB (0.73) MAOBMEN1KMT2AALDH1A1ALOX12
SCHEMBL14005157 0.79 HDAC1 (0.68) HDAC1LMNAMAPK1RAB9A
SCHEMBL28402820 0.78 HDAC1 (1.00) HDAC1MAOB
SCHEMBL14004681 0.78 HDAC6 (0.66) HDAC1ALDH1A1LMNARECQLGAA
SCHEMBL11686091 0.77 PTGS2 (0.70) MEN1KMT2AALDH1A1GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4030925-A Photographic compositions and elements including internal latent image silver halide grains and acylhydrazinophenylthiourea nucleating agents therefor EASTMAN KODAK COMPANY (US) 1977-06-21 US claimed
US-4031127-A Acyl hydrazino thiourea derivatives as photographic nucleating agents EASTMAN KODAK COMPANY (US) 1977-06-21 US claimed
US-4030925-A Photographic compositions and elements including internal latent image silver halide grains and acylhydrazinophenylthiourea nucleating agents therefor EASTMAN KODAK COMPANY (US) 1977-06-21 US disclosed
US-4031127-A Acyl hydrazino thiourea derivatives as photographic nucleating agents EASTMAN KODAK COMPANY (US) 1977-06-21 US disclosed