Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of E-Doxepin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 1.00 |
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 1.00 |
| ▸ | HTR2B | P41595 | 6/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | SLC22A1 | O15245 | 2/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 2/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 2/20 | 1.00 |
| ▸ | HTR1A | P08908 | 2/20 | 1.00 |
| ▸ | CHRM5 | P08912 | 2/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 2/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 2/20 | 1.00 |
| ▸ | DRD2 | P14416 | 2/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 2/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 2/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 2/20 | 1.00 |
| ▸ | DRD1 | P21728 | 2/20 | 1.00 |
| ▸ | DRD4 | P21917 | 2/20 | 1.00 |
| ▸ | DRD5 | P21918 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cidoxepin SCHEMBL29493441 | 1.00 | HTR2B (1.00) | HTR2BHRH1KCNH2ALDH1A1SLC6A2 | |
| Doxepin SCHEMBL31349647 | 1.00 | HTR2B (1.00) | HTR2BHRH1KCNH2ALDH1A1SLC6A2 | |
| Cidoxepin SCHEMBL684837 | 1.00 | HTR2B (1.00) | HTR2BHRH1KCNH2ALDH1A1SLC6A2 | |
| Doxepin SCHEMBL28054 | 1.00 | HTR2B (1.00) | HTR2BHRH1KCNH2ALDH1A1SLC6A2 | |
| Cidoxepin SCHEMBL29368454 | 0.99 | ALDH1A1 (1.00) | HTR2BHRH1KCNH2ALDH1A1SLC6A2 | |
| Doxepin SCHEMBL5655381 | 0.99 | HTR2B (0.97) | HTR2BHRH1KCNH2ALDH1A1SLC6A2 | |
| Doxepin SCHEMBL1281891 | 0.99 | ALDH1A1 (1.00) | HTR2BHRH1KCNH2ALDH1A1SLC6A2 | |
| Doxepin SCHEMBL29359800 | 0.99 | ALDH1A1 (1.00) | HTR2BHRH1KCNH2ALDH1A1SLC6A2 | |
| Doxepin SCHEMBL41532 | 0.99 | ALDH1A1 (1.00) | HTR2BHRH1KCNH2ALDH1A1SLC6A2 | |
| Cidoxepin SCHEMBL124597 | 0.99 | ALDH1A1 (1.00) | HTR2BHRH1KCNH2ALDH1A1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4035 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260034106-A1 | Macrocyclic ligands for FK506-binding proteins for treatment of diseases with improved characteristics | UNIV DARMSTADT TECH (DE) | 2026-02-05 | — | — | US | claimed |
| EP-4686495-A1 | MACROCYCLIC LIGANDS FOR FK506-BINDING PROTEINS FOR TREATMENT OF DISEASES WITH IMPROVED CHARACTERISTICS | Technische Universität Darmstadt (DE) | 2026-02-04 | — | — | EP | claimed |
| EP-4659817-A2 | LIPOSOME COMPOSITION FOR USE IN PERITONEAL DIALYSIS | Versantis AG (CH) | 2025-12-10 | — | — | EP | claimed |
| EP-4208466-B1 | HIGH AFFINITY MACROCYCLIC FKB51-INHIBITORS FOR TREATMENT OF PSYCHIATRIC DISORDERS | UNIV DARMSTADT TECH (DE) | 2025-06-11 | — | — | EP | claimed |
| US-20250152605-A1 | METHOD AND DRUG FOR TREATING NEURONAL CEROID LIPOFUSCINOSIS | TSINGHUA UNIVERSITY (CN) | 2025-05-15 | — | — | US | claimed |
| US-20250135164-A1 | Controlled Release Of A Hydrophilic Agent From A Coated Surface | BIOCOAT, INCORPORATED | 2025-05-01 | — | — | US | claimed |
| US-12239634-B2 | Methods of treating pruritus | CLEXIO BIOSCIENCES LTD. (IL) | 2025-03-04 | — | — | US | claimed |
| WO-2025024501-A1 | NEUROMODULATORY PEPTIDES | LACTOCORE, INC. (US) | 2025-01-30 | — | — | WO | claimed |
| US-20250032503-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | HOTH THERAPEUTICS, INC. | 2025-01-30 | — | — | US | claimed |
| EP-4497471-A2 | STIMULATION OF NEURONAL PLASTICITY | Institute of Science and Technology Austria (AT) | 2025-01-29 | — | — | EP | claimed |
| WO-1994023700-A1 | HIGH RELEASE SOLID PREPARATION, PREPARATION AND USE THEREOF | RIJKSUNIVERSITEIT GENT LABORATORIUM VOOR FARMACEUTISCHE TECHNOLOGIE (BE) | 1994-10-27 | — | — | WO | claimed |
| US-5338757-A | Administering antihistamines | THE PENN STATE RESEARCH FOUNDATION (US) | 1994-08-16 | — | — | US | claimed |
| EP-0367746-B1 | Sustained release drug-resin complexes | RICHARDSON VICKS INC (US) | 1994-02-02 | — | — | EP | claimed |
| EP-0177344-B1 | SERUM PRETREATMENT FOR TRICYCLIC ANTIDEPRESSANT DRUG ASSAYS AND KIT THEREFOR | SYNTEX (U.S.A.) INC. (US) | 1992-04-08 | — | — | EP | claimed |
| EP-0280290-B1 | AGENT HAVING AN ANTIDEPRESSIVE ACTIVITY | BOEHRINGER INGELHEIM KG (DE) | 1992-01-08 | — | — | EP | claimed |
| EP-0126684-B1 | DRUG DELIVERY SYSTEM UTILIZING THERMOSETTING GELS | MERCK & CO. INC. (US) | 1991-08-28 | — | — | EP | claimed |
| US-5019591-A | Antihistamines | PENNSYLVANIA RESEARCH CORPORATION (US) | 1991-05-28 | — | — | US | claimed |
| US-4977145-A | ADMINISTERING ANGIOTENSIN CONVERTING ENZYME INHIBITOR AND ANTIDEPRESSANT | E. R. SQUIBB & SONS, INC. (US) | 1990-12-11 | — | — | US | claimed |
| EP-0174342-B1 | BRAIN-SPECIFIC ANALOGUES OF CENTRALLY ACTING AMINES | UNIVERSITY OF FLORIDA (US) | 1989-12-20 | — | — | EP | claimed |
| EP-0107134-B1 | TRICYCLIC ANTIDEPRESSANT DRUG IMMUNOGENS, ANTIBODIES, LABELED CONJUGATES, AND RELATED DERIVATIVES | MILES LABORATORIES, INC. (US) | 1986-04-09 | — | — | EP | claimed |