Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Doxepin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 0.97 |
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 1.00 |
| ▸ | RECQL | P46063 | 1/20 | 1.00 |
| ▸ | HTR2B | P41595 | 6/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.97 |
| ▸ | LMNA | P02545 | 3/20 | 0.97 |
| ▸ | MEN1 | O00255 | 2/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.97 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.97 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.97 |
| ▸ | HTR1A | P08908 | 2/20 | 0.97 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.97 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.97 |
| ▸ | DRD2 | P14416 | 2/20 | 0.97 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Doxepin SCHEMBL3408702 | 1.00 | ALDH1A1 (1.00) | ALDH1A1KDM4EPMP22RECQLHTR2B | |
| Cidoxepin SCHEMBL29368454 | 1.00 | ALDH1A1 (1.00) | ALDH1A1KDM4EPMP22RECQLHTR2B | |
| Doxepin SCHEMBL29359800 | 1.00 | ALDH1A1 (1.00) | ALDH1A1KDM4EPMP22RECQLHTR2B | |
| E-Doxepin SCHEMBL60287 | 1.00 | ALDH1A1 (1.00) | ALDH1A1KDM4EPMP22RECQLHTR2B | |
| Doxepin SCHEMBL41532 | 1.00 | ALDH1A1 (1.00) | ALDH1A1KDM4EPMP22RECQLHTR2B | |
| Cidoxepin SCHEMBL124597 | 1.00 | ALDH1A1 (1.00) | ALDH1A1KDM4EPMP22RECQLHTR2B | |
| Doxepin SCHEMBL29018844 | 0.99 | ALDH1A1 (0.97) | ALDH1A1KDM4EPMP22RECQLHTR2B | |
| Cidoxepin SCHEMBL684837 | 0.99 | HTR2B (1.00) | ALDH1A1KDM4EPMP22RECQLHTR2B | |
| Doxepin SCHEMBL31349647 | 0.99 | HTR2B (1.00) | ALDH1A1KDM4EPMP22RECQLHTR2B | |
| Doxepin SCHEMBL28054 | 0.99 | HTR2B (1.00) | ALDH1A1KDM4EPMP22RECQLHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120088822-A1 | LOW-DOSE DOXEPIN FOR TREATMENT OF SLEEP DISORDERS IN ELDERLY PATIENTS | SOMAXON PHARMACEUTICALS, INC. (US) | 2012-04-12 | — | — | US | disclosed |
| US-20110178166-A1 | METHODS OF USING LOW-DOSE DOXEPIN FOR THE IMPROVEMENT OF SLEEP | SOMAXON PHARMACEUTICALS, INC. (US) | 2011-07-21 | — | — | US | disclosed |
| US-5643897-A | Treatment for insomnia | PROCOM ONE, INC. | 1997-07-01 | — | — | US | disclosed |
| US-5502047-A | DOXEPIN | PROCOM ONE, INC. | 1996-03-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088822-A1 | LOW-DOSE DOXEPIN FOR TREATMENT OF SLEEP DISORDERS IN ELDERLY PATIENTS | UBQLN1, UBQLN2, USP47 | HRH1 477/4885SLC6A2 1209/4885ALDH1A1 2947/4885 |
| US-20110178166-A1 | METHODS OF USING LOW-DOSE DOXEPIN FOR THE IMPROVEMENT OF SLEEP | PER2, BCHE, MTNR1A | HRH1 436/4885SLC6A2 648/4885ALDH1A1 3713/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.