Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Doxepin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 0.97 |
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 1.00 |
| ▸ | RECQL | P46063 | 1/20 | 1.00 |
| ▸ | HTR2B | P41595 | 6/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.97 |
| ▸ | LMNA | P02545 | 3/20 | 0.97 |
| ▸ | MEN1 | O00255 | 2/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.97 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.97 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.97 |
| ▸ | HTR1A | P08908 | 2/20 | 0.97 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.97 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.97 |
| ▸ | DRD2 | P14416 | 2/20 | 0.97 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Doxepin SCHEMBL1281891 | 1.00 | ALDH1A1 (1.00) | ALDH1A1KDM4EPMP22RECQLHTR2B | |
| Doxepin SCHEMBL3408702 | 1.00 | ALDH1A1 (1.00) | ALDH1A1KDM4EPMP22RECQLHTR2B | |
| Cidoxepin SCHEMBL29368454 | 1.00 | ALDH1A1 (1.00) | ALDH1A1KDM4EPMP22RECQLHTR2B | |
| Doxepin SCHEMBL29359800 | 1.00 | ALDH1A1 (1.00) | ALDH1A1KDM4EPMP22RECQLHTR2B | |
| E-Doxepin SCHEMBL60287 | 1.00 | ALDH1A1 (1.00) | ALDH1A1KDM4EPMP22RECQLHTR2B | |
| Cidoxepin SCHEMBL124597 | 1.00 | ALDH1A1 (1.00) | ALDH1A1KDM4EPMP22RECQLHTR2B | |
| Doxepin SCHEMBL29018844 | 0.99 | ALDH1A1 (0.97) | ALDH1A1KDM4EPMP22RECQLHTR2B | |
| Cidoxepin SCHEMBL684837 | 0.99 | HTR2B (1.00) | ALDH1A1KDM4EPMP22RECQLHTR2B | |
| Doxepin SCHEMBL31349647 | 0.99 | HTR2B (1.00) | ALDH1A1KDM4EPMP22RECQLHTR2B | |
| Doxepin SCHEMBL28054 | 0.99 | HTR2B (1.00) | ALDH1A1KDM4EPMP22RECQLHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 5584 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122005474-A | Doxepin hydrochloride tablet and preparation method thereof | 苏州弘森药业股份有限公司 | 2026-05-12 | — | — | CN | claimed |
| US-20250152605-A1 | METHOD AND DRUG FOR TREATING NEURONAL CEROID LIPOFUSCINOSIS | TSINGHUA UNIVERSITY (CN) | 2025-05-15 | — | — | US | claimed |
| WO-2025082994-A1 | NEW FORMULATIONS OF PITOLISANT AND METHODS OF USE | BIOPROJET PHARMA (FR) | 2025-04-24 | — | — | WO | claimed |
| US-20250120918-A1 | NEW FORMULATIONS OF PITOLISANT AND METHODS OF USE | BIOPROJET PHARMA (FR) | 2025-04-17 | — | — | US | claimed |
| WO-2025024501-A1 | NEUROMODULATORY PEPTIDES | LACTOCORE, INC. (US) | 2025-01-30 | — | — | WO | claimed |
| US-20250032503-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | HOTH THERAPEUTICS, INC. | 2025-01-30 | — | — | US | claimed |
| CN-116239562-B | Method for synthesizing doxepin hydrochloride by taking benzofuranone as raw material | 江苏师范大学 | 2024-12-31 | — | — | CN | claimed |
| CN-113573723-B | Synthetic neuromodulatory peptides | 拉托科公司 | 2024-12-03 | — | — | CN | claimed |
| US-20240390316-A1 | USE OF DOXEPIN HYDROCHLORIDE IN PREPARATION OF ANTIVIRAL DRUG | SHENZHEN TECHNOLOGY UNIVERSITY (CN) | 2024-11-28 | — | — | US | claimed |
| US-20240307386-A1 | NOVEL METHODS | INTRA-CELLULAR THERAPIES, INC. | 2024-09-19 | — | — | US | claimed |
| EP-0247960-B1 | GUIDE FOR SLIDING CURTAINS AND SIMILAR | KLEIN-IBERICA, S.A. (ES) | 1990-12-05 | — | — | EP | claimed |
| EP-0247960-A1 | Guide for sliding curtains and similar | KLEIN-IBERICA, S.A. (ES) | 1987-12-02 | — | — | EP | claimed |
| US-4693291-A | Curtain-hook assembly | ANDREWS LINDA S | 1987-09-15 | — | — | US | claimed |
| US-4539199-A | AMINE SALT OF ACRYLIC ACID-ACRYLIC ESTER COPOLYMER | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 1985-09-03 | — | — | US | claimed |
| EP-0147780-A2 | Drug delivery device | MERCK & CO. INC. (US) | 1985-07-10 | — | — | EP | claimed |
| US-4505909-A | Method and composition for treating and preventing irritation of the eyes | BERNSTEIN JOEL E (US) | 1985-03-19 | — | — | US | claimed |
| US-4395420-A | APPLYING DOXEPIN | BERNSTEIN, JOEL E. | 1983-07-26 | — | — | US | claimed |
| US-4370324-A | Method and composition for treating and preventing irritation of the eyes | BERNSTEIN JOEL E (US) | 1983-01-25 | — | — | US | claimed |
| EP-0048023-A2 | Composition for treating and preventing irritation of the eyes | Bernstein, Joel E., M.D. (US) | 1982-03-24 | — | — | EP | claimed |
| US-4017658-A | FLOOR OR WALL COVERINGS, DECORATION, GELATION OF TRANSPARENT PLASTISOL | EUROFLOOR S.A. (LU) | 1977-04-12 | — | — | US | claimed |