Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | CASR | P41180 | 1/20 | 0.54 |
| ▸ | MMP9 | P14780 | 2/20 | 0.50 |
| ▸ | MMP8 | P22894 | 2/20 | 0.50 |
| ▸ | TLR2 | O60603 | 1/20 | 0.49 |
| ▸ | MME | P08473 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MMP14 | P50281 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27518632 | 0.85 | POLB (0.57) | POLBMEN1KMT2ACTDSP1HDAC8 | |
| SCHEMBL12012717 | 0.85 | CTSK (0.56) | POLBMEN1KMT2ACTDSP1CASR | |
| SCHEMBL27518634 | 0.85 | POLB (0.57) | POLBMEN1KMT2ACTDSP1HDAC8 | |
| SCHEMBL15338785 | 0.85 | CTSK (0.56) | POLBMEN1KMT2ACTDSP1CASR | |
| SCHEMBL8760756 | 0.84 | POLB (0.53) | POLBMEN1KMT2ACTDSP1HDAC8 | |
| SCHEMBL7313409 | 0.84 | POLB (0.55) | POLBMEN1KMT2ACTDSP1HDAC8 | |
| SCHEMBL417597 | 0.84 | POLB (0.59) | POLBMEN1KMT2ACTDSP1HDAC8 | |
| SCHEMBL7313421 | 0.84 | POLB (0.55) | POLBMEN1KMT2ACTDSP1HDAC8 | |
| SCHEMBL418739 | 0.84 | POLB (0.59) | POLBMEN1KMT2ACTDSP1HDAC8 | |
| SCHEMBL13338038 | 0.81 | POLB (0.57) | POLBMEN1KMT2ACTDSP1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110034513-A1 | Heterocyclic Sulfonamide Inhibitors of Beta Amyloid Production | WYETH LLC (US) | 2011-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034513-A1 | Heterocyclic Sulfonamide Inhibitors of Beta Amyloid Production | APP, BACE1, PSEN1 | POLB 3197/4885MEN1 1105/4885KMT2A 1866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.