Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | CASR | P41180 | 1/20 | 0.50 |
| ▸ | CTSC | P53634 | 2/20 | 0.47 |
| ▸ | MMP9 | P14780 | 2/20 | 0.47 |
| ▸ | MMP8 | P22894 | 2/20 | 0.47 |
| ▸ | MMP14 | P50281 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.45 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7313421 | 1.00 | POLB (0.55) | POLBCTDSP1MEN1KMT2AMAPT | |
| SCHEMBL7303552 | 0.87 | CTSC (0.48) | CTSC | |
| SCHEMBL1168971 | 0.84 | POLB (0.64) | POLBCTDSP1MEN1KMT2AMAPT | |
| SCHEMBL7305453 | 0.82 | CNR1 (0.57) | CASRCTSC | |
| SCHEMBL27518634 | 0.81 | POLB (0.57) | POLBCTDSP1MEN1KMT2AMAPT | |
| SCHEMBL27518632 | 0.81 | POLB (0.57) | POLBCTDSP1MEN1KMT2AMAPT | |
| SCHEMBL7317840 | 0.80 | CTSC (0.51) | CTSC | |
| SCHEMBL9111863 | 0.78 | POLB (0.52) | POLBCTDSP1MEN1KMT2AMAPT | |
| SCHEMBL12312074 | 0.78 | MEN1 (0.62) | POLBCTDSP1MEN1KMT2AMAPT | |
| SCHEMBL7374474 | 0.78 | MMP2 (0.47) | CTSC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1041064-A2 | N-substituted alpha aminoacid amides as calcium channel modulators | ELI LILLY AND COMPANY LIMITED (GB) | 2000-10-04 | — | — | EP | disclosed |
| EP-0805147-A1 | Novel N-substituted alpha aminoacid amides as calcium channel modulators | LILLY INDUSTRIES LIMITED (GB) | 1997-11-05 | — | — | EP | disclosed |