Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | BMP1 | P13497 | 1/20 | 0.57 |
| ▸ | CXCR3 | P49682 | 5/20 | 0.56 |
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.50 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1287296 | 0.92 | MAPT (0.54) | TP53MAPTBMP1CXCR3TAS2R14 | |
| SCHEMBL1169305 | 0.91 | TP53 (0.70) | TP53MAPTCXCR3TAS2R14MEN1 | |
| SCHEMBL1170016 | 0.87 | PSEN1 (0.64) | TP53MAPTCXCR3TAS2R14MEN1 | |
| SCHEMBL1169357 | 0.86 | TAS2R14 (0.75) | TP53CXCR3TAS2R14MEN1KMT2A | |
| SCHEMBL1169742 | 0.86 | TP53 (0.79) | TP53MAPTCXCR3TAS2R14MEN1 | |
| SCHEMBL1169272 | 0.85 | TAS2R14 (0.70) | TP53MAPTCXCR3TAS2R14MEN1 | |
| SCHEMBL1287419 | 0.83 | PSEN1 (0.52) | TP53MAPTBMP1POLBSMN1; SMN2 | |
| SCHEMBL1675861 | 0.83 | PSEN1 (0.52) | TP53MAPTBMP1POLBSMN1; SMN2 | |
| SCHEMBL15396095 | 0.83 | PSEN1 (0.52) | TP53MAPTBMP1POLBSMN1; SMN2 | |
| SCHEMBL1168910 | 0.82 | TAS2R14 (0.70) | TP53MAPTCXCR3TAS2R14MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110028509-A1 | Sulfonamides | MERCK SERONO SA (CH) | 2011-02-03 | — | — | US | disclosed |
| US-20110028509-A1 | Sulfonamides | MERCK SERONO SA (CH) | 2011-02-03 | — | — | US | disclosed |
| US-20110028509-A1 | Sulfonamides | MERCK SERONO SA (CH) | 2011-02-03 | — | — | US | disclosed |
| WO-2009124962-A2 | SULFONAMIDES | MERCK SERONO S.A. (CH) | 2009-10-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028509-A1 | Sulfonamides | CXCR3, CXCR2, CXCR1 | TP53 1636/4885MAPT 4698/4885BMP1 4686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.