Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | BMP1 | P13497 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.47 |
| ▸ | CXCR3 | P49682 | 3/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1169732 | 0.92 | TP53 (0.60) | MAPTPOLBMEN1KMT2ABMP1 | |
| SCHEMBL1287492 | 0.89 | PSEN1 (0.58) | MAPTPOLBMEN1KMT2ATP53 | |
| SCHEMBL1287395 | 0.88 | MEN1 (0.69) | POLBMEN1KMT2ADAGLATAS2R14 | |
| SCHEMBL1287263 | 0.88 | POLB (0.69) | MAPTPOLBMEN1KMT2ABMP1 | |
| SCHEMBL1169305 | 0.83 | TP53 (0.70) | MAPTPOLBMEN1KMT2ATP53 | |
| SCHEMBL1170016 | 0.80 | PSEN1 (0.64) | MAPTPOLBMEN1KMT2ATP53 | |
| SCHEMBL1287503 | 0.79 | TAS2R14 (0.71) | POLBMEN1KMT2ATAS2R14CXCR3 | |
| SCHEMBL1287322 | 0.79 | MEN1 (0.65) | POLBMEN1KMT2ATAS2R14CXCR3 | |
| SCHEMBL1169742 | 0.79 | TP53 (0.79) | MAPTPOLBMEN1KMT2ATP53 | |
| SCHEMBL1169357 | 0.79 | TAS2R14 (0.75) | POLBMEN1KMT2ATP53DAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047926-A2 | SULFONAMIDE-CONTAINING COMPOUNDS | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2012-04-12 | — | — | WO | disclosed |