Fenretinide

Fenretinide

SCHEMBL11704

CC(C=CC1=C(C)CCCC1(C)C)=CC=CC(C)=CC(=O)Nc1ccc(O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RBP4 P02753 7/20 1.00
ALDH1A1 P00352 7/20 1.00
MAPT P10636 5/20 1.00
HIF1A Q16665 4/20 1.00
CYP3A4 P08684 4/20 1.00
HSD17B10 Q99714 3/20 1.00
MAPK1 P28482 3/20 1.00
BLM P54132 3/20 1.00
LMNA P02545 3/20 1.00
KDM4E B2RXH2 2/20 1.00
MEN1 O00255 2/20 1.00
GMNN O75496 2/20 1.00
ALOX15 P16050 2/20 1.00
NFKB1 P19838 2/20 1.00
MTOR P42345 2/20 1.00
PMP22 Q01453 2/20 1.00
KMT2A Q03164 2/20 1.00
SMN1; SMN2 Q16637 2/20 1.00
CYP2C9 P11712 2/20 1.00
CYP2C19 P33261 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fenretinide SCHEMBL4996036 1.00 RBP4 (1.00) RBP4ALDH1A1MAPTHIF1ACYP3A4
Fenretinide SCHEMBL839699 1.00 RBP4 (1.00) RBP4ALDH1A1MAPTHIF1ACYP3A4
Fenretinide SCHEMBL13402304 1.00 RBP4 (1.00) RBP4ALDH1A1MAPTHIF1ACYP3A4
Fenretinide SCHEMBL9838209 1.00 RBP4 (1.00) RBP4ALDH1A1MAPTHIF1ACYP3A4
Fenretinide SCHEMBL19121 1.00 RBP4 (1.00) RBP4ALDH1A1MAPTHIF1ACYP3A4
Fenretinide SCHEMBL15703189 1.00 RBP4 (1.00) RBP4ALDH1A1MAPTHIF1ACYP3A4
Fenretinide SCHEMBL10629371 1.00 RBP4 (1.00) RBP4ALDH1A1MAPTHIF1ACYP3A4
Fenretinide SCHEMBL11703 1.00 RBP4 (1.00) RBP4ALDH1A1MAPTHIF1ACYP3A4
Fenretinide SCHEMBL4874840 1.00 RBP4 (1.00) RBP4ALDH1A1MAPTHIF1ACYP3A4
Fenretinide SCHEMBL17593790 0.99 RBP4 (0.98) RBP4ALDH1A1MAPTHIF1ACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 25336 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3841097-B1 2,6-BIS(((1H-BENZO[D]IMIDAZOL-2-YL)THIO)METHYL)PYRIDINE AND N2,N6-DIBENZYLPYRIDINE-2,6-DICARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE (PI3K) INHIBITORS FOR TREATING CANCER BIOMEDICAL RES FOUNDATION OF THE ACADEMY OF ATHENS BRFAA (GR) 2026-05-20 EP claimed
US-20260116861-A1 ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-04-30 US claimed
EP-4727979-A2 COMPOSITIONS AND METHODS FOR TARGETING EXTRACELLULAR DNA Caris Science, Inc. (US) 2026-04-22 EP claimed
EP-3515892-B1 COMPOUNDS AND METHODS FOR IDO AND TDO MODULATION, AND INDICATIONS THEREFOR PLEXXIKON INC (US) 2026-04-15 EP claimed
US-12522572-B2 Isoxazole hydroxamic acids as histone deacetylase 6 inhibitors THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-01-13 US claimed
EP-4673152-A2 COMBINATIONS FOR TREATMENT OF PARKINSON'S DISEASE AND OTHER PRIMARY AND SECONDARY PARKINSONIAN DISORDERS Kenai Therapeutics Inc. (US) 2026-01-07 EP claimed
US-20260000663-A1 RBP4 ANTAGONISTS FOR TREATMENT AND PREVENTION OF NON-ALCOHOLIC FATTY LIVER DISEASE AND GOUT THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2026-01-01 US claimed
US-12509444-B2 Compounds and methods for CD73 modulation and indications therefor PLEXXIKON INC. (US) 2025-12-30 US claimed
US-20250382580-A1 COMPOSITIONS AND METHODS FOR ACCELERATED PRODUCTION OF THYMIC CELLS FROM PLURIPOTENT STEM CELLS UNIV COLORADO REGENTS (US) 2025-12-18 US claimed
EP-4654969-A1 COMPOUNDS AND METHODS FOR YAP/TEAD MODULATION AND INDICATIONS THEREFOR Opna Bio SA (CH) 2025-12-03 EP claimed
WO-1999001118-A2 ANTIOXIDANT ENHANCEMENT OF THERAPY FOR HYPERPROLIFERATIVE CONDITIONS ATHEROGENICS, INC. (US) 1999-01-14 WO claimed
EP-0711276-A1 PROCESS FOR THE PREPARATION OF N-(4-HYDROXYPHENYL)-RETINAMIDE ORTHO PHARMACEUTICAL CORPORATION (US) 1996-05-15 EP claimed
US-5464870-A Antitumor ORTHO PHARMACEUTICAL CORPORATION (US) 1995-11-07 US claimed
US-5399757-A Process for the preparation of N-(4-hydroxyphenyl)-retinamide ORTHO PHARMACEUTICAL CORPORATION (US) 1995-03-21 US claimed
WO-1995003274-A1 PROCESS FOR THE PREPARATION OF N-(4-HYDROXYPHENYL)-RETINAMIDE ORTHO PHARMACEUTICAL CORPORATION (US) 1995-02-02 WO claimed
EP-0393575-B1 Neoplasia treatment compositions containing antineoplastic agent and side-effect reducing protective agent SEARLE & CO (US) 1994-03-16 EP claimed
US-5010107-A Dietary supplement of calcium glucarate to inhibit beta-glucoronidase and N-hydroxyphenyl retinamide to elevate cyclic AMP OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) 1991-04-23 US claimed
US-5008291-A Dietary supplement containing calcium glucarate and n-(4-hydroxyphenyl)retinamide; treating mammary cancer OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) 1991-04-16 US claimed
EP-0393575-A1 Neoplasia treatment compositions containing antineoplastic agent and side-effect reducing protective agent G.D. Searle & Co. (US) 1990-10-24 EP claimed
US-4665098-A BREAST AND BLADDER CANCER, ACNE, PSORIASIS MCNEILAB, INC. (US) 1987-05-12 US claimed