SCHEMBL11705239

SCHEMBL11705239

Brc1ccc(COc2ccc(Cn3ccnc3)cc2)cc1

nearest known ligand 0.74

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 6/20 0.74
CYP11B2 P19099 4/20 0.74
CYP19A1 P11511 3/20 0.74
MAPK1 P28482 1/20 0.61
TBXAS1 P24557 2/20 0.59
NOS1 P29475 2/20 0.58
HMOX1 P09601 2/20 0.58
CYP2A6 P11509 1/20 0.54
CYP2B6 P20813 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31307775 0.88 CYP19A1 (0.61) CYP11B1CYP11B2CYP19A1MAPK1TBXAS1
SCHEMBL11701053 0.87 CYP11B1 (0.73) CYP11B1CYP11B2CYP19A1TBXAS1HMOX1
SCHEMBL7477480 0.87 HMOX1 (0.75) CYP11B1CYP11B2CYP19A1TBXAS1HMOX1
SCHEMBL707075 0.86 CYP11B1 (1.00) CYP11B1CYP11B2CYP19A1TBXAS1HMOX1
SCHEMBL11702884 0.86 CYP19A1 (0.67) CYP11B1CYP11B2CYP19A1TBXAS1HMOX1
SCHEMBL11701540 0.86 CYP19A1 (0.74) CYP11B1CYP11B2CYP19A1TBXAS1HMOX1
SCHEMBL31307770 0.82 HMOX1 (0.77) CYP11B1CYP11B2CYP19A1TBXAS1NOS1
SCHEMBL11707006 0.81 FNTA (0.57) CYP11B1CYP11B2CYP19A1TBXAS1HMOX1
SCHEMBL20601860 0.80 TBXAS1 (0.67) CYP11B1CYP11B2CYP19A1TBXAS1CYP2A6
SCHEMBL20661392 0.80 CYP11B1 (0.56) CYP11B1CYP11B2CYP19A1TBXAS1HMOX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4006243-A FUNGICIDE, BACTERICIDE, YEAST SCHERING AKTIENGESELLSCHAFT (DT) 1977-02-01 US claimed
US-4006243-A FUNGICIDE, BACTERICIDE, YEAST SCHERING AKTIENGESELLSCHAFT (DT) 1977-02-01 US disclosed