Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMOX1 | P09601 | 1/20 | 0.75 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.71 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.71 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.71 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.71 |
| ▸ | QPCT | Q16769 | 2/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.71 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.71 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.63 |
| ▸ | LTA4H | P09960 | 1/20 | 0.60 |
| ▸ | FNTA | P49354 | 1/20 | 0.60 |
| ▸ | FNTB | P49356 | 1/20 | 0.60 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11701053 | 0.88 | CYP11B1 (0.73) | HMOX1CYP11B1CYP11B2CYP19A1TBXAS1 | |
| SCHEMBL11705239 | 0.87 | CYP11B1 (0.74) | HMOX1CYP11B1CYP11B2CYP19A1TBXAS1 | |
| SCHEMBL17407551 | 0.87 | CYP11B1 (0.64) | HMOX1CYP11B1CYP11B2CYP19A1TBXAS1 | |
| SCHEMBL11702884 | 0.87 | CYP19A1 (0.67) | HMOX1CYP11B1CYP11B2CYP19A1TBXAS1 | |
| SCHEMBL11701540 | 0.87 | CYP19A1 (0.74) | HMOX1CYP11B1CYP11B2CYP19A1TBXAS1 | |
| SCHEMBL8389054 | 0.87 | CYP19A1 (0.68) | HMOX1CYP11B1CYP11B2CYP19A1TBXAS1 | |
| SCHEMBL31307697 | 0.86 | CYP19A1 (0.74) | HMOX1CYP11B1CYP11B2CYP19A1TBXAS1 | |
| SCHEMBL8390116 | 0.85 | TBXAS1 (0.65) | HMOX1CYP11B1CYP11B2CYP19A1TBXAS1 | |
| SCHEMBL22063900 | 0.84 | CYP11B1 (1.00) | CYP11B1CYP11B2CYP19A1TBXAS1QPCT | |
| Benzylimidazole SCHEMBL414 | 0.84 | CYP11B1 (1.00) | CYP11B1CYP11B2CYP19A1TBXAS1QPCT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020035092-A1 | Inhibit binding of alpha-v integrins to their ligands, use in treatment of immune and inflammatory disorders; 3-(4-(2-Aminoethyl)benzamide)-3-(2-(4-(2-pyridylamino)methyl) phenoxy)-4-pyrimidinyl)propanoic acid | CELLTECH THERAPEUTICS LIMITED | 2002-03-21 | — | — | US | disclosed |
| US-6319922-B1 | ALPHA-PYRIMIDYL-SUBSTITUTED; USEFUL FOR TREATING DISEASES INCLUDING INFLAMMATORY DISEASES, AND DISEASES INVOLVING ANGIOGENESIS, BONE RESORPTION OR CELLULAR OR MATRIX OVER-EXPANSION. | CELLTECH THERAPEUTICS LIMITED (GB) | 2001-11-20 | — | — | US | disclosed |
| EP-1133488-A1 | PROPANOIC ACID DERIVATIVES AS INTEGRIN INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 2001-09-19 | — | — | EP | disclosed |
| WO-2000031067-A1 | PROPANOIC ACID DERIVATIVES AS INTEGRIN INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-06-02 | — | — | WO | disclosed |
| US-5100890-A | Antidepressants, Fungicides | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-03-31 | — | — | US | disclosed |
| EP-0218118-B1 | ARYLMETHYL AZOLES AND THEIR SALTS, METHOD FOR THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-09-18 | — | — | EP | disclosed |
| US-5023357-A | Arylmethylazole preparation processes | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-06-11 | — | — | US | disclosed |
| US-4876354-A | FUNGICIDES, ANTIDEPRESSANTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-10-24 | — | — | US | disclosed |
| EP-0218118-A1 | Arylmethyl azoles and their salts, method for their preparation, compositions containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-04-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020035092-A1 | Inhibit binding of alpha-v integrins to their ligands, use in treatment of immune and inflammatory disorders; 3-(4-(2-Aminoethyl)benzamide)-3-(2-(4-(2-pyridylamino)methyl) phenoxy)-4-pyrimidinyl)propanoic acid | ITGA1, ITGB1, VCAM1 | HMOX1 3504/4885CYP11B1 1957/4885CYP11B2 2766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.