Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | GALR3 | O60755 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 10/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SLFN12 | Q8IYM2 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9655901 | 0.87 | L3MBTL1 (0.56) | L3MBTL1MAPTGALR3SMN1; SMN2THRB | |
| SCHEMBL9654303 | 0.87 | MAPT (0.48) | L3MBTL1MAPTGALR3SMN1; SMN2THRB | |
| SCHEMBL9656255 | 0.86 | MAPT (0.47) | L3MBTL1MAPTGALR3SMN1; SMN2THRB | |
| SCHEMBL9654315 | 0.86 | MAPT (0.47) | L3MBTL1MAPTGALR3SMN1; SMN2THRB | |
| SCHEMBL11633588 | 0.83 | L3MBTL1 (0.60) | L3MBTL1MAPTPDE3BPDE3ALMNA | |
| SCHEMBL9654443 | 0.81 | MAPT (0.46) | L3MBTL1MAPTGALR3SMN1; SMN2THRB | |
| SCHEMBL9654426 | 0.80 | MAPT (0.46) | L3MBTL1MAPTGALR3SMN1; SMN2THRB | |
| SCHEMBL10568606 | 0.79 | MAPT (0.44) | L3MBTL1MAPTGALR3SMN1; SMN2THRB | |
| SCHEMBL9657403 | 0.79 | MAPT (0.44) | L3MBTL1MAPTGALR3SMN1; SMN2THRB | |
| SCHEMBL10555382 | 0.78 | ADRB2 (0.58) | MAPTLMNAADRB2ADRB1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4011321-A | 6-(3-SUBSTITUTED AMINO-2-HYDROXYPROPOXYARYL)-4,5-DIHYDRO-3(2H)-PYRIDAZINONES | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-03-08 | — | — | US | disclosed |