Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | ADRB2 | P07550 | 10/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 8/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11704925 | 0.93 | L3MBTL1 (0.52) | L3MBTL1ADRB2ADRB1HTR1AOPRK1 | |
| SCHEMBL11634308 | 0.86 | ACHE (0.53) | L3MBTL1ADRB2ADRB1HTR1AOPRK1 | |
| SCHEMBL11703709 | 0.85 | ADRB2 (0.49) | ADRB2ADRB1HTR1AOPRK1PDE4B | |
| SCHEMBL11700085 | 0.85 | PDE4B (0.60) | ADRB2ADRB1HTR1AOPRK1PDE4B | |
| SCHEMBL11634268 | 0.85 | ADRB2 (0.49) | ADRB2ADRB1HTR1AOPRK1PDE4B | |
| SCHEMBL9462545 | 0.84 | L3MBTL1 (0.46) | L3MBTL1ADRB2ADRB1HTR1AOPRK1 | |
| SCHEMBL11704716 | 0.84 | ADRB2 (0.50) | L3MBTL1ADRB2ADRB1HTR1AOPRK1 | |
| SCHEMBL11705278 | 0.83 | L3MBTL1 (0.57) | L3MBTL1ADRB2ADRB1HTR1AOPRK1 | |
| SCHEMBL11706953 | 0.83 | ADRB2 (0.49) | ADRB2ADRB1HTR1AOPRK1PDE4B | |
| Hydrochloric Acid SCHEMBL11706892 | 0.83 | ADRB2 (0.49) | L3MBTL1ADRB2ADRB1HTR1AOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4082843-A | 3-(3-(3-Substituted amino-2-hydroxypropoxy)phenyl)-6-hydrazino pyridazines and their use as vasodilators and β-adrenergic blocking agents | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1978-04-04 | — | — | US | disclosed |