Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.72 |
| ▸ | RAB9A | P51151 | 6/20 | 0.72 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | MAOB | P27338 | 1/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.58 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.57 |
| ▸ | SCD | O00767 | 1/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.57 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11707756 | 0.93 | NPC1 (0.71) | NPC1RAB9AIRAK4POLBMEN1 | |
| SCHEMBL11706151 | 0.88 | NPC1 (0.72) | NPC1RAB9AIRAK4POLBMEN1 | |
| SCHEMBL11707254 | 0.85 | NPC1 (0.64) | NPC1RAB9AIRAK4POLBMEN1 | |
| SCHEMBL11206434 | 0.84 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL11707745 | 0.82 | NPC1 (0.71) | NPC1RAB9AIRAK4POLBMEN1 | |
| SCHEMBL2683695 | 0.81 | NPC1 (0.72) | NPC1RAB9AIRAK4POLBMEN1 | |
| SCHEMBL11171725 | 0.81 | LMNA (0.63) | NPC1POLBMEN1KMT2AHRH4 | |
| SCHEMBL28642016 | 0.81 | NPC1 (0.57) | NPC1RAB9APOLBMEN1KMT2A | |
| SCHEMBL11766588 | 0.80 | TUBB4A (0.66) | NPC1RAB9AIRAK4POLBMEN1 | |
| SCHEMBL31329345 | 0.79 | NPC1 (0.74) | NPC1RAB9AIRAK4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4011236-A | N-(BENZIMIDAZOL-2-YL)ARYLCARBOXAMIDES AS ULTRAVIOLET (UV) LIGHT ABSORBERS | MERCK & CO., INC. (US) | 1977-03-08 | — | — | US | disclosed |