Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 12/20 | 0.72 |
| ▸ | RAB9A | P51151 | 12/20 | 0.72 |
| ▸ | MEN1 | O00255 | 5/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | PKM | P14618 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | MAOB | P27338 | 1/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.58 |
| ▸ | KLF5 | Q13887 | 3/20 | 0.57 |
| ▸ | SCD | O00767 | 1/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11707745 | 0.93 | NPC1 (0.71) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL11706161 | 0.88 | NPC1 (0.72) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL11707239 | 0.85 | NPC1 (0.64) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL11206434 | 0.84 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL9893032 | 0.84 | LMNA (0.63) | NPC1RAB9AMEN1KMT2AKLF5 | |
| SCHEMBL11707756 | 0.82 | NPC1 (0.71) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL11171719 | 0.81 | NPC1 (0.55) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL28642015 | 0.81 | NPC1 (0.57) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL25956581 | 0.81 | IRAK4 (0.84) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL11766577 | 0.80 | TUBB4A (0.57) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4011236-A | N-(BENZIMIDAZOL-2-YL)ARYLCARBOXAMIDES AS ULTRAVIOLET (UV) LIGHT ABSORBERS | MERCK & CO., INC. (US) | 1977-03-08 | — | — | US | disclosed |