Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 1/20 | 0.49 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | RHEB | Q15382 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5798490 | 0.88 | TSHR (0.52) | PDE7APDE7BL3MBTL1MAPK1CA12 | |
| SCHEMBL11705929 | 0.85 | PDE7A (0.48) | PDE7APDE7BL3MBTL1MAPK1CA12 | |
| SCHEMBL9323068 | 0.81 | ABL1 (0.53) | PDE7APDE7BL3MBTL1MAPK1CA12 | |
| SCHEMBL11476180 | 0.80 | SIRT1 (0.67) | L3MBTL1MAPK1CA12CA1CA2 | |
| SCHEMBL8769572 | 0.78 | TSHR (0.45) | L3MBTL1MAPK1CA1CA2MEN1 | |
| SCHEMBL11453246 | 0.77 | SMN1; SMN2 (0.44) | L3MBTL1MAPK1CA1CA2MEN1 | |
| SCHEMBL3784717 | 0.76 | PDE7A (0.59) | PDE7APDE7BL3MBTL1MAPK1RHEB | |
| SCHEMBL8607500 | 0.75 | SMN1; SMN2 (0.42) | MAPK1LMNAMEN1KMT2ATSHR | |
| SCHEMBL28016921 | 0.75 | HSD17B10 (0.70) | PDE7APDE7BL3MBTL1MAPK1CA12 | |
| SCHEMBL4436373 | 0.75 | ALDH1A1 (0.56) | CA12CA1CA2CA4CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4022774-A | DIURETICS | E. R. SQUIBB & SONS, INC. (US) | 1977-05-10 | — | — | US | disclosed |
| US-3957769-A | DIURETICS, CENTRAL NERVOUS SYSTEM DEPRESSANTS | E. R. SQUIBB & SONS, INC. (US) | 1976-05-18 | — | — | US | disclosed |