Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPY1R | P25929 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11193713 | 0.83 | P2RX7 (0.51) | MAPTKDM4ELMNAHTR2C | |
| SCHEMBL11202328 | 0.83 | KDM4E (0.53) | MAPTKDM4EJAK2JAK1TYK2 | |
| SCHEMBL11194179 | 0.82 | KDM4E (0.61) | MAPTKDM4EJAK2JAK1TYK2 | |
| SCHEMBL11713201 | 0.74 | JAK2 (0.46) | NPY1RJAK2JAK1TYK2JAK3 | |
| Hydrochloric Acid SCHEMBL11195502 | 0.72 | P2RX7 (0.54) | MAPTLMNAHTR2CTDP1 | |
| SCHEMBL7690760 | 0.70 | NPY1R (0.80) | NPY1R | |
| SCHEMBL24549320 | 0.69 | TDP1 (0.61) | KDM4ELMNATDP1 | |
| Hydrochloric Acid SCHEMBL11201456 | 0.69 | P2RX7 (0.65) | MAPTLMNAHTR2C | |
| SCHEMBL11199073 | 0.68 | LMNA (0.70) | MAPTJAK2JAK1TYK2JAK3 | |
| SCHEMBL11713594 | 0.68 | BACE1 (0.64) | BACE1NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4035369-A | 1-Benzazolylalkyl-4-substituted-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1977-07-12 | — | — | US | disclosed |