Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11712424 | 1.00 | LMNA (0.45) | LMNAMAPTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL11717512 | 1.00 | LMNA (0.45) | LMNAMAPTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL13036975 | 0.92 | BCHE (0.44) | LMNAMAPTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL13036977 | 0.90 | SMN1; SMN2 (0.45) | LMNAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL10460913 | 0.90 | MAPT (0.42) | LMNAMAPTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL12909 | 0.87 | SMN1; SMN2 (0.50) | LMNAALDH1A1KMT2AHRH3TSHR | |
| SCHEMBL13036981 | 0.85 | KDM4E (0.44) | LMNAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL8294664 | 0.84 | KMT2A (0.51) | LMNAMAPTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL935060 | 0.82 | ALDH1A1 (0.60) | LMNAMAPTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL11811902 | 0.81 | CYP1A2 (0.41) | LMNAMAPTALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4012396-A | Processes and intermediates for cis or trans 2-or 3-(1-acyl-3-vinyl-4-piperidine)acetic or propionic acid esters | HOFFMANN-LA ROCHE INC. (US) | 1977-03-15 | — | — | US | disclosed |
| US-3959294-A | Processes and intermediates for cis or trans 2- or 3-(1-acyl-3-vinyl-4-piperidine)acetic or propionic acid esters | HOFFMANN-LA ROCHE INC. (US) | 1976-05-25 | — | — | US | disclosed |
| US-3957800-A | PROCESSES AND INTERMEDIATES FOR CIS OR TRANS 2- OR 3-(1-ACYL-3-VINYL-4-PIPERIDINE)ACETIC OR PROPIONIC ACID ESTERS | HOFFMANN-LA ROCHE INC. (US) | 1976-05-18 | — | — | US | disclosed |