Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 6/20 | 0.39 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11717512 | 0.87 | LMNA (0.45) | SMN1; SMN2ALDH1A1TSHRKMT2ALMNA | |
| SCHEMBL11712424 | 0.87 | LMNA (0.45) | SMN1; SMN2ALDH1A1TSHRKMT2ALMNA | |
| SCHEMBL11709792 | 0.87 | LMNA (0.45) | SMN1; SMN2ALDH1A1TSHRKMT2ALMNA | |
| SCHEMBL11811902 | 0.83 | CYP1A2 (0.41) | SMN1; SMN2ALDH1A1BCHEKDM2BLMNA | |
| SCHEMBL13960292 | 0.83 | BCHE (0.40) | SMN1; SMN2ALDH1A1KMT2ABCHEKDM2B | |
| SCHEMBL13036974 | 0.83 | CYP1A2 (0.41) | SMN1; SMN2ALDH1A1BCHEKDM2BLMNA | |
| SCHEMBL13036983 | 0.81 | L3MBTL1 (0.53) | SMN1; SMN2ALDH1A1KMT2ABCHEKDM2B | |
| SCHEMBL12449670 | 0.81 | KMT2A (0.56) | SMN1; SMN2ALDH1A1KMT2ALMNAHRH3 | |
| SCHEMBL12649 | 0.81 | KMT2A (0.56) | SMN1; SMN2ALDH1A1KMT2ALMNAHRH3 | |
| SCHEMBL14609741 | 0.81 | SMN1; SMN2 (0.64) | SMN1; SMN2ALDH1A1TSHRKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499146-B1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2016-09-21 | — | — | EP | disclosed |
| WO-2011058149-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-05-19 | — | — | WO | disclosed |