Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA3 | P34903 | 11/20 | 0.63 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.63 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.63 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.63 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.63 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 7/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 7/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11732204 | 0.88 | GABRA3 (0.64) | GABRA3GABRA1GABRA2GABRA5GABRB2 | |
| SCHEMBL29783033 | 0.84 | GABRA3 (0.73) | GABRA3GABRA1GABRA2GABRA5GABRB2 | |
| SCHEMBL11828965 | 0.84 | GABRA3 (0.73) | GABRA3GABRA1GABRA2GABRA5GABRB2 | |
| SCHEMBL11834518 | 0.81 | GABRA3 (0.63) | GABRA3GABRA1GABRA2GABRA5GABRB2 | |
| SCHEMBL19006771 | 0.81 | GABRA3 (0.66) | GABRA3GABRA1GABRA2GABRA5GABRB2 | |
| SCHEMBL11709742 | 0.81 | GABRA3 (0.66) | GABRA3GABRA1GABRA2GABRA5GABRB2 | |
| SCHEMBL11838549 | 0.80 | GABRA1 (0.70) | GABRA3GABRA1GABRA2GABRA5GABRB2 | |
| SCHEMBL11727011 | 0.80 | GABRA3 (0.53) | GABRA3GABRA1GABRA2GABRA5GABRB2 | |
| SCHEMBL11865356 | 0.79 | GABRA1 (0.80) | GABRA3GABRA1GABRA2GABRA5GABRB2 | |
| SCHEMBL7380104 | 0.79 | GABRA3 (0.58) | GABRA3GABRA1GABRA2GABRA5GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4005099-A | 1-[(Dimethylamino)-methyl]-6-aryl-4H-imidazo[1,5-a][1,4]benzodiazepines | THE UPJOHN COMPANY (US) | 1977-01-25 | — | — | US | disclosed |