Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 6/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1171340 | 1.00 | GCK (0.51) | GCKAKR1C3AKR1C2AKR1C1KCNH2 | |
| SCHEMBL1171737 | 0.99 | GCK (0.52) | GCKAKR1C3AKR1C2AKR1C1KCNH2 | |
| SCHEMBL1171734 | 0.99 | GCK (0.52) | GCKAKR1C3AKR1C2AKR1C1KCNH2 | |
| SCHEMBL1171742 | 0.91 | GCK (0.48) | GCK | |
| SCHEMBL1171740 | 0.91 | GCK (0.48) | GCK | |
| SCHEMBL2669024 | 0.90 | GCK (0.53) | GCKKCNH2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL1171342 | 0.87 | GCK (0.50) | GCKKCNH2TAS1R3TAS1R2 | |
| SCHEMBL1107285 | 0.86 | GCK (0.49) | GCKKCNH2 | |
| SCHEMBL2648502 | 0.84 | GCK (0.39) | GCKTAS1R3TAS1R2 | |
| SCHEMBL2648496 | 0.84 | GCK (0.39) | GCKTAS1R3TAS1R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110040091-A1 | PROCESS FOR THE PREPARATION OF (R)-2-PHENYL PROPIONIC ACID DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2011-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110040091-A1 | PROCESS FOR THE PREPARATION OF (R)-2-PHENYL PROPIONIC ACID DERIVATIVES | PCCA, GRHPR, GABRR2 | GCK 970/4885AKR1C3 7/4885AKR1C2 27/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.