GABRR2

Gamma-aminobutyric acid receptor subunit rho-2 · P28476 · GABRR2 on Sugi Atlas →

8,212 patent compounds predicted against GABRR2, 5,294 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Fumaric Acid (SCHEMBL786567)	0.58	3/20
Maleic Acid (SCHEMBL786851)	0.58	3/20
Maleic Acid (SCHEMBL558296)	0.55	3/20
Fumaric Acid (SCHEMBL558298)	0.55	3/20
Ethylenediamine (SCHEMBL909940)	0.47	3/20
Acrylic Acid (SCHEMBL1399480)	0.46	3/20
Acrylic Acid (SCHEMBL1085535)	0.39	3/20
Acrylic Acid (SCHEMBL1399478)	0.39	3/20
Propionic Acid (SCHEMBL45569)	0.36	3/20
Acrylamide (SCHEMBL1417837)	0.33	3/20
SCHEMBL273087	0.58	2/20
SCHEMBL847719	0.52	2/20
SCHEMBL483126	0.50	2/20
SCHEMBL585108	0.50	2/20
SCHEMBL585109	0.50	2/20
Fumaric Acid (SCHEMBL365675)	0.47	2/20
Fumaric Acid (SCHEMBL365677)	0.47	2/20
Maleic Acid (SCHEMBL1062042)	0.47	2/20
Fumaric Acid (SCHEMBL1062045)	0.47	2/20
Fumaric Acid (SCHEMBL6875)	0.47	2/20

Clinical trials — most relevant to GABRR2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Computational Assessment of GABA Receptor Modulation in PTSD	PHASE4	RECRUITING
Safety of Ramelteon in Elderly Subjects	PHASE4	COMPLETED
The Effects of Levetiracetam on Alcohol Dependent Subjects	PHASE4	COMPLETED
Safety and Efficacy Study of Ramelteon in Subjects With Chronic Insomnia	PHASE3	COMPLETED
Efficacy and Safety of Ramelteon Combined With Gabapentin in Treating Patients With Insomnia	PHASE2	COMPLETED
Safety and Efficacy of Ramelteon and Doxepin in Subjects With Chronic Insomnia	PHASE2	COMPLETED
Efficacy of Bumetanide to Improve Cognitive Functions in Down Syndrome	PHASE2	RECRUITING
A Multicenter Study of NAP (AL-108) in Schizophrenia	PHASE2	COMPLETED
Neurosteroids and Acute Alcohol Intoxication in Humans	PHASE1	UNKNOWN
MEG Study of Acute STX209 Effects in ASD	EARLY_PHASE1	COMPLETED
Synaptic Mechanisms of Continuous Theta Burst Stimulation in Depression	EARLY_PHASE1	RECRUITING
Pilot Study Evaluating Neuro-Imaging Correlates of Epigenetic Finding in Prediction of Chronic Postsurgical Pain	nan	UNKNOWN
GABA Biomarkers in Dravet Syndrome	nan	RECRUITING
Association of Brain Derived Neurotrophic Factor (BDNF) rs6265 Gene Polymorphism With Susceptibility to Epilepsy	nan	UNKNOWN
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services	nan	UNKNOWN
Potential Synergistic Effect of Combined Blood Flow Restriction Training and Betaine Supplementation on Skeletal Muscle	nan	COMPLETED
The Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on Working Memory	nan	COMPLETED
GABRA2 and the Pharmacokinetics of Risk for Alcoholism (GPRA)	nan	COMPLETED
The Neuroprotective Effect of Dexmedetomidine Preserving Brain Functional Connectivity in Elderly Patients	nan	COMPLETED
Transcriptomic Profile of Patients Treated With Different Modalities of Spinal Cord Stimulation	nan	UNKNOWN
Protocol Assessment of Motor Cortex rTMS for Treating Neuropathic Pain	nan	RECRUITING
Acute Intermittent Hypoxia in Traumatic Brain Injury	nan	COMPLETED
Cenobamate Efficacy in Individuals With Autoimmune Epilepsy	nan	ENROLLING_BY_INVITATION
The Efficacy of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery.	nan	COMPLETED
Investigating the Role of Diazepam on Brain Function and Chemistry in Psychosis Risk	nan	COMPLETED
Acute Asthma Responsiveness and B2 Adrenergic Receptors Polymorphisms	nan	COMPLETED
A Positional Cloning Study on Schizophrenia	nan	COMPLETED
Brain Changes in Patients With Focal Hand Dystonia	nan	COMPLETED
Integrins and Protocadherins in Glutamatergic Circuits: Identification of Common Signaling Pathways and Molecular Targets in Anxiety and Major Depressive Disorders (GAPsy)	nan	UNKNOWN
Exploring the Role of the Prefrontal Cortex in Decision-Making	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a GABRR2 binder may also engage these)

Protein	Name	Similarity
P50572	—	1.000	P50572 →
Q0II76	—	1.000	Q0II76 →
P47742	—	1.000	P47742 →
P56476	—	1.000	P56476 →
GABRR1	Gamma-aminobutyric acid receptor subunit rho-1	0.997	landscape →
P56475	—	0.994	P56475 →
P50573	—	0.990	P50573 →
GABRR3	Gamma-aminobutyric acid receptor subunit rho-	0.986	landscape →
Q08832	—	0.964	Q08832 →
P02713	—	0.956	P02713 →
P20237	—	0.950	P20237 →
GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	0.949	landscape →
P20782	—	0.948	P20782 →
Q9PTS8	—	0.948	Q9PTS8 →
Q708S4	—	0.945	Q708S4 →
Q94900	—	0.945	Q94900 →
P28471	—	0.944	P28471 →
P09660	—	0.943	P09660 →
P24045	—	0.943	P24045 →
P26714	—	0.942	P26714 →
Q68RJ7	—	0.942	Q68RJ7 →
Q9D6F4	—	0.941	Q9D6F4 →
P02715	—	0.941	P02715 →
P25109	—	0.939	P25109 →
CHRNE	Acetylcholine receptor subunit epsilon	0.939	landscape →
P04758	—	0.939	P04758 →
CHRNA9	Neuronal acetylcholine receptor subunit alpha-9	0.938	landscape →
P02714	—	0.938	P02714 →
Q708S6	—	0.937	Q708S6 →
P02717	—	0.936	P02717 →