Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.62 |
| ▸ | GCK | P35557 | 13/20 | 0.52 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.37 |
| ▸ | GRN | P28799 | 1/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1171353 | 1.00 | KCNH2 (0.62) | KCNH2GCKAPPPSEN1PSEN2 | |
| SCHEMBL1171463 | 0.99 | KCNH2 (0.63) | KCNH2GCKAPPPSEN1PSEN2 | |
| SCHEMBL1171465 | 0.99 | KCNH2 (0.63) | KCNH2GCKAPPPSEN1PSEN2 | |
| SCHEMBL1171354 | 0.98 | KCNH2 (0.62) | KCNH2GCKAPPPSEN1PSEN2 | |
| SCHEMBL1859324 | 0.96 | KCNH2 (0.60) | KCNH2GCKAPPPSEN1PSEN2 | |
| SCHEMBL1859322 | 0.96 | KCNH2 (0.60) | KCNH2GCKAPPPSEN1PSEN2 | |
| SCHEMBL1171102 | 0.91 | KCNH2 (0.58) | KCNH2GCKAPPPSEN1PSEN2 | |
| SCHEMBL1445384 | 0.89 | KCNH2 (0.63) | KCNH2GCKMEN1KMT2ATBXA2R | |
| SCHEMBL2668907 | 0.89 | KCNH2 (0.63) | KCNH2GCKMEN1KMT2A | |
| SCHEMBL1445381 | 0.89 | KCNH2 (0.63) | KCNH2GCKMEN1KMT2ATBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110040091-A1 | PROCESS FOR THE PREPARATION OF (R)-2-PHENYL PROPIONIC ACID DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2011-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110040091-A1 | PROCESS FOR THE PREPARATION OF (R)-2-PHENYL PROPIONIC ACID DERIVATIVES | PCCA, GRHPR, GABRR2 | KCNH2 159/4885GCK 970/4885APP 1000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.