Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 10/20 | 0.54 |
| ▸ | RORA | P35398 | 14/20 | 0.49 |
| ▸ | RORC | P51449 | 14/20 | 0.49 |
| ▸ | RORB | Q92753 | 14/20 | 0.49 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.48 |
| ▸ | PARG | Q86W56 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11713896 | 0.88 | PGR (0.52) | PGRRORARORCRORBNR1H3 | |
| SCHEMBL11713598 | 0.88 | PGR (0.66) | PGRRORARORCRORBNR1H3 | |
| SCHEMBL11713888 | 0.83 | PGR (0.58) | PGRRORARORCRORBNR1H3 | |
| SCHEMBL6363131 | 0.71 | MAPK8 (0.64) | PGRRORARORCRORB | |
| SCHEMBL22016212 | 0.70 | PARG (0.50) | PARG | |
| SCHEMBL17242025 | 0.68 | PARG (0.48) | RORARORCRORBPARG | |
| SCHEMBL10084702 | 0.66 | TP53 (0.59) | RORARORCRORBPARG | |
| SCHEMBL14934089 | 0.65 | HDAC1 (0.42) | PGRNR1H3PARG | |
| SCHEMBL21024140 | 0.65 | HPD (0.47) | PGRRORARORCRORBGRM2 | |
| SCHEMBL21024141 | 0.65 | GRM2 (0.48) | PGRRORARORCRORBPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4058612-A | HYPOTENSIVE AGENTS | SCHERING CORPORATION (US) | 1977-11-15 | — | — | US | disclosed |