Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 6/20 | 0.50 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.40 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24312051 | 0.83 | KDM4E (0.57) | PARGKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL24312203 | 0.79 | ALDH1A1 (0.43) | PARGPLK1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL22017360 | 0.78 | KDM4E (0.43) | PARGPLK1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL17298315 | 0.76 | KDM4E (0.47) | KDM4EALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL6363131 | 0.74 | MAPK8 (0.64) | KDM4EALDH1A1HSD17B10MAPK1MAPK8 | |
| SCHEMBL13376862 | 0.74 | PGR (0.64) | PARGPLK1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL11713598 | 0.71 | PGR (0.66) | PARG | |
| SCHEMBL28750653 | 0.70 | PARG (0.50) | PARGKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL10084699 | 0.70 | RORA (0.52) | PARGKDM4EHPDPDE4AADORA2A | |
| SCHEMBL11713601 | 0.70 | PGR (0.54) | PARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2023-02-09 | — | — | US | disclosed |
| US-11116760-B2 | Quinoline derivatives | GILEAD SCIENCES, INC. (US) | 2021-09-14 | — | — | US | disclosed |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | PARG 4220/4885PLK1 421/4885KDM4E 2522/4885 |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | PARG 4220/4885PLK1 421/4885KDM4E 2522/4885 |
| US-11116760-B2 | Quinoline derivatives | CFTR, NQO1, IRF3 | PARG 4220/4885PLK1 421/4885KDM4E 2522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.