Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 8/20 | 0.58 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.55 |
| ▸ | GHSR | Q92847 | 4/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11713218 | 0.85 | ALDH1A1 (0.63) | MTNR1BGHSR | |
| SCHEMBL11720526 | 0.84 | MTNR1B (0.54) | HCRTR1HCRTR2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL11716476 | 0.83 | GHSR (0.57) | GHSR | |
| SCHEMBL11716164 | 0.83 | GHSR (0.57) | GHSR | |
| SCHEMBL11712160 | 0.82 | ALDH1A1 (0.49) | MTNR1BGHSRMTNR1A | |
| SCHEMBL11715513 | 0.81 | NPC1 (0.51) | GHSR | |
| SCHEMBL11712540 | 0.81 | NPC1 (0.48) | MTNR1BGHSRMTNR1A | |
| SCHEMBL11715350 | 0.80 | GHSR (0.49) | GHSR | |
| SCHEMBL11714332 | 0.80 | GHSR (0.49) | GHSR | |
| SCHEMBL11720578 | 0.80 | MEN1 (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4001244-A | 1-ARYL-3,4-DIHYDRO-2(1H)-ISOQUINOLINE CARBONYL CHLORIDES | G. D. SEARLE & CO. (US) | 1977-01-04 | — | — | US | disclosed |