Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLP1R | P43220 | 1/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11723530 | 0.88 | CCNE2 (0.32) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL11720257 | 0.82 | GLP1R (0.34) | GLP1RCCNE2CDK4CCND1CCNE1 | |
| SCHEMBL11723495 | 0.81 | CCNE2 (0.33) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL11725434 | 0.80 | ALDH1A1 (0.30) | — | |
| SCHEMBL5143956 | 0.72 | SMN1; SMN2 (0.35) | GLP1RCDK2LMNAPOLBHTT | |
| SCHEMBL11733104 | 0.71 | POLB (0.42) | CDK2POLBHTT | |
| SCHEMBL11720169 | 0.70 | CCNA2 (0.44) | CDK2 | |
| SCHEMBL11716809 | 0.70 | TRPM8 (0.37) | GLP1R | |
| SCHEMBL11725267 | 0.68 | GLP1R (0.36) | GLP1RLMNAPOLBHTT | |
| SCHEMBL11738829 | 0.67 | ALDH1A1 (0.40) | CCNE2CCNE1CDK2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4055649-A | 4-Alkyl-2,6-di-(secondary or tertiary alkyl)amino-3-formylpyridines pharmaceutical compositions thereof and their use in the treatment of obesity and diabetes | SANDOZ, INC. (US) | 1977-10-25 | — | — | US | disclosed |