Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | SRPK3 | Q9UPE1 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | XBP1 | P17861 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11716323 | 0.86 | KDM4E (0.67) | NPSR1KDM4EALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL11716572 | 0.83 | ALDH1A1 (0.61) | NPSR1KDM4EALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL11720308 | 0.80 | KDM4E (0.64) | NPSR1KDM4EALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL5485870 | 0.77 | KDM4E (1.00) | NPSR1KDM4EALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL11784892 | 0.77 | KDM4E (0.79) | NPSR1KDM4EALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL5483674 | 0.76 | CYP1A2 (0.54) | KDM4EALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL5483672 | 0.76 | CYP1A2 (0.54) | KDM4EALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL1647152 | 0.75 | LRRK2 (1.00) | LRRK2KDM4ESGMS2SMN1; SMN2MAPT | |
| SCHEMBL1646963 | 0.75 | LRRK2 (1.00) | LRRK2SRPK3SGMS2 | |
| SCHEMBL1432938 | 0.74 | ALDH1A1 (0.72) | NPSR1KDM4EALDH1A1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4013670-A | ANTIARRHYTHMICS | RIKER LABORATORIES, INC. (US) | 1977-03-22 | — | — | US | claimed |
| US-4013670-A | ANTIARRHYTHMICS | RIKER LABORATORIES, INC. (US) | 1977-03-22 | — | — | US | disclosed |
| US-4005209-A | Antiarrhythmic method utilizing fluoroalkoxy-N-piperidyl and pyridyl benzamides | RIKER LABORATORIES, INC. (US) | 1977-01-25 | — | — | US | disclosed |