Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 8/20 | 0.54 |
| ▸ | CYP1A1 | P04798 | 7/20 | 0.54 |
| ▸ | CYP1B1 | Q16678 | 7/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5483674 | 1.00 | CYP1A2 (0.54) | CYP1A2CYP1A1CYP1B1CYP3A4CYP2D6 | |
| SCHEMBL5478757 | 0.87 | KDM4E (0.60) | CYP1A2CYP3A4KDM4EALDH1A1CYP2C9 | |
| SCHEMBL5478754 | 0.87 | KDM4E (0.60) | CYP1A2CYP3A4KDM4EALDH1A1CYP2C9 | |
| SCHEMBL5486508 | 0.83 | MAPT (0.59) | CYP1A2CYP3A4KDM4EALDH1A1CYP2C9 | |
| SCHEMBL5486515 | 0.83 | MAPT (0.59) | CYP1A2CYP3A4KDM4EALDH1A1CYP2C9 | |
| SCHEMBL5475281 | 0.82 | ALDH1A1 (0.53) | CYP1A2CYP3A4KDM4EALDH1A1CYP2C9 | |
| SCHEMBL5475283 | 0.82 | ALDH1A1 (0.53) | CYP1A2CYP3A4KDM4EALDH1A1CYP2C9 | |
| SCHEMBL5479415 | 0.81 | KDM4E (0.53) | CYP1A2CYP3A4KDM4EALDH1A1CYP2C9 | |
| SCHEMBL5479421 | 0.81 | KDM4E (0.53) | CYP1A2CYP3A4KDM4EALDH1A1CYP2C9 | |
| SCHEMBL5482544 | 0.81 | KDM4E (0.58) | CYP1A2CYP1A1CYP1B1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256219-B2 | Multifluoro-substituted chalcones and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. (US) | 2007-08-14 | — | — | US | claimed |
| US-20040171637-A1 | Multifluoro-substituted chalcones and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. | 2004-09-02 | — | — | US | claimed |
| WO-2002072544-A2 | MULTIFLUORO-SUBSTITUTED CHALCONES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2002-09-19 | — | — | WO | claimed |
| US-7256219-B2 | Multifluoro-substituted chalcones and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. (US) | 2007-08-14 | — | — | US | disclosed |
| US-20040171637-A1 | Multifluoro-substituted chalcones and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. | 2004-09-02 | — | — | US | disclosed |
| WO-2002072544-A2 | MULTIFLUORO-SUBSTITUTED CHALCONES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2002-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040171637-A1 | Multifluoro-substituted chalcones and analogs as activators of caspases and inducers of apoptosis and the use thereof | CASP10, CASP6, CASP1 | CYP1A2 954/4885CYP1A1 253/4885CYP1B1 203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.