Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | CCR4 | P51679 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2051899 | 0.91 | DCTPP1 (0.48) | DCTPP1SMN1; SMN2MAPTCNR1CNR2 | |
| SCHEMBL2053158 | 0.90 | CSF1R (0.48) | DCTPP1SMN1; SMN2MAPTCNR1CNR2 | |
| SCHEMBL1171802 | 0.87 | DCTPP1 (0.59) | DCTPP1SMN1; SMN2MAPTCNR1CNR2 | |
| SCHEMBL2048737 | 0.86 | PLA2G2A (0.44) | DCTPP1CNR1CNR2RAB9A | |
| SCHEMBL3009404 | 0.82 | DCTPP1 (0.50) | DCTPP1SMN1; SMN2MAPTCNR1CNR2 | |
| SCHEMBL2051309 | 0.81 | CSF1R (0.42) | DCTPP1ALDH1A1 | |
| SCHEMBL17406695 | 0.81 | CNR2 (0.49) | DCTPP1SMN1; SMN2CNR1CNR2CCR4 | |
| SCHEMBL2052032 | 0.80 | CSF1R (0.42) | DCTPP1MAPTRAB9A | |
| SCHEMBL30592410 | 0.80 | CNR2 (0.48) | SMN1; SMN2CNR1CNR2CCR4KDM4E | |
| SCHEMBL26110001 | 0.80 | CNR2 (0.48) | SMN1; SMN2CNR1CNR2CCR4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110046108-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046108-A1 | PYRIMIDINE DERIVATIVES | EPHB4, EPHB1, EPHB3 | DCTPP1 706/4885SMN1; SMN2 3091/4885MAPT 3778/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.