Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | CCR4 | P51679 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1172483 | 0.87 | DCTPP1 (0.55) | DCTPP1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL9941525 | 0.87 | LMNA (0.47) | DCTPP1CNR1CNR2KDM4ELMNA | |
| SCHEMBL15312556 | 0.81 | CSF1R (0.42) | DCTPP1CYP3A4LMNATDP1ALDH1A1 | |
| SCHEMBL2051899 | 0.80 | DCTPP1 (0.48) | DCTPP1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL15312682 | 0.80 | DCTPP1 (0.42) | DCTPP1RAB9AMAPTCYP3A4CYP2C9 | |
| SCHEMBL30630478 | 0.79 | CNR2 (0.49) | DCTPP1SMN1; SMN2MAPTCNR1CNR2 | |
| SCHEMBL1172531 | 0.79 | CYP1A2 (0.52) | DCTPP1SMN1; SMN2MAPTCNR1CNR2 | |
| SCHEMBL25248761 | 0.79 | DCTPP1 (0.51) | DCTPP1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL2053158 | 0.79 | CSF1R (0.48) | DCTPP1NPC1SMN1; SMN2MAPTCNR1 | |
| SCHEMBL3287293 | 0.79 | DCTPP1 (0.58) | DCTPP1NPC1RAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110046108-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046108-A1 | PYRIMIDINE DERIVATIVES | EPHB4, EPHB1, EPHB3 | DCTPP1 706/4885NPC1 2858/4885RAB9A 1703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.